PMID: 6275847Sep 15, 1981Paper

Inactivation of rat liver glucocorticoid receptor by molybdate. Effects on both non-activated and activated receptor complexes

The Biochemical Journal
N Murakami, V K Moudgil


When freshly prepared glucocorticoid-receptor complex from rat liver cytosol was incubated at 23 degrees C in the presence of sodium molybdate, its subsequent binding to isolated nuclei, DNA-cellulose and ATP-Sepharose was blocked. In addition, binding to these acceptors by cytosol receptor complex fractionated with (NH4)2SO4 was also blocked by incubation of the complexes with 50 mM-sodium molybdate. However, molybdate had no effect on the binding of activated receptor complexes to ATP-Sepharose. Molybdate was also effective in extracting the nuclear- and DNA-cellulose-bound glucocorticoid-receptor complexes in a dose-dependent manner. Molybdate appears to exert its effects directly on the receptor by interacting with both non-activated and activated receptor forms.


Jul 1, 1983·The Journal of Urology·B J DonnellyW A McBlain
Dec 10, 1990·Biochimica Et Biophysica Acta·V K Moudgil
Feb 1, 1984·Journal of Steroid Biochemistry·W G LuttgeC L Densmore
Aug 1, 1985·Journal of Steroid Biochemistry·V K Moudgil, V M Caradonna
Jun 1, 1983·Journal of Steroid Biochemistry·M N AlexisC E Sekeris
Jan 1, 1988·Journal of Steroid Biochemistry·T NemotoM Ota
Feb 1, 1987·Molecular and Cellular Endocrinology·G P Rossini
Jun 1, 1987·Journal of Steroid Biochemistry·C E RekerW V Vedeckis
Mar 1, 1982·Archives of Biochemistry and Biophysics·N MurakamiV K Moudgil

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