PMID: 8610966Feb 13, 1996Paper

Inactivation of Th1 and Th2 cells by feeding ovalbumin

Annals of the New York Academy of Sciences
A M MowatP Garside

Abstract

Several different mechanisms have been implicated in oral tolerance to protein antigens, depending on the nature and dose of antigen used and the species under study. Here, we have investigated the basis of unresponsiveness in a well-established model of oral tolerance in mice fed 25 mg ovalbumin (OVA). Our results show that CD8+ T-cell activity is suppressed by feeding OVA and that these cells are not required for the induction of tolerance. CD4+ T cells are essential for tolerance to occur, but both Th1 and Th2 cell-dependent functions are tolerized equally in OVA-fed mice. Peripheral lymph node cells from tolerized mice rapidly undergo apoptosis when cultured in vitro but produce substantial amounts of transforming growth factor beta (TGFbeta) in response to OVA. The appearance of tolerance in vivo is preceded by a transient phase of T-cell priming, and we propose that this model of oral tolerance reflects partial activation of T cells by fed antigen, leading to selective production of TGFbeta and consequent inactivation of all effector T cells. These findings indicate that the active suppression and clonal anergy identified previously in mice with oral tolerance may not be mutually exclusive phenomena.

References

Mar 1, 1995·International Immunology·P GarsideA M Mowat
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·A Friedman, H L Weiner

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Citations

Dec 4, 1998·Springer Seminars in Immunopathology·H L Weiner, Y Komagata
Mar 16, 2007·Journal of Clinical Immunology·Jona FreysdottirArnor Vikingsson
Jun 6, 2000·Advanced Drug Delivery Reviews·J W Simecka
May 20, 1998·Research in Immunology·J M Benson, C C Whitacre
May 20, 1998·Research in Immunology·M G von Herrath
Oct 31, 1998·Current Opinion in Immunology·S Cobbold, H Waldmann
Oct 12, 2004·Inflammatory Bowel Diseases·Robin L Jump, Alan D Levine
Nov 6, 2012·Advanced Drug Delivery Reviews·Xiaomei WangRoland W Herzog
Jun 1, 2006·Neurosurgical Focus·G LanzinoE R Laws
Jul 29, 2005·Immunological Reviews·Ana M C Faria, Howard L Weiner
Oct 10, 2001·European Journal of Immunology·M KarlssonE Telemo
Feb 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Iriani T TobagusPatrick G Holt
Feb 1, 2005·Annals of the New York Academy of Sciences·Howard L Weiner

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