Inactivation of the dorsal or ventral hippocampus with muscimol differentially affects fear and memory

Brain Research
Kristopher McEown, Dallas Treit

Abstract

It was recently found that temporary inactivation of the dorsal hippocampus with lidocaine impaired fear memory, whereas temporary inactivation of the ventral hippocampus did not. These site-specific deficits, however, may have resulted from disruption of axonal signals arriving from structures outside of the hippocampus, or from disruption of axons that pass through the hippocampus entirely. This is problematic because the hippocampus receives extensive afferent input from both the amygdala and the septum, which also play very important roles in fear and fear memory. To mitigate this problem, rats were infused with the GABA(A) receptor agonist muscimol, into either the dorsal or the ventral hippocampus, just after an "acquisition" session in which the rats were shocked from an electrified probe. A "retention" test in the same apparatus was conducted 24h later, when the hippocampus was no longer inactivated, and the probe was no longer electrified. Dorsal hippocampal inactivation just after acquisition impaired conditioned fear behavior (probe avoidance) during the retention test, whereas ventral hippocampal inactivation after acquisition did not. However, muscimol inactivation of the ventral hippocampus during an "acquisition"...Continue Reading

References

Oct 16, 1980·Nature·M Gavish, S H Snyder
Jun 24, 1982·Nature·R G MorrisJ O'Keefe
Aug 1, 2002·Proceedings of the National Academy of Sciences of the United States of America·Kirsten G KjelstrupMay-Britt Moser
Mar 19, 2003·Behavioural Brain Research·D M BannermanJ N P Rawlins
Jun 13, 2003·Drug Discovery Today·Paul J Whiting
Jan 20, 2004·Nature Neuroscience·Steven R LavioletteDerek van der Kooy
Feb 20, 2004·Brain Research·Aldemar Degroot, Dallas Treit
Feb 26, 2004·Behavioral Neuroscience·S B McHughD M Bannerman
Aug 17, 2005·Current Pharmaceutical Design·H A FozzardG M Lipkind
Sep 30, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kevin A CorcoranStephen Maren
Nov 8, 2005·Journal of Neuroscience Research·Evangelos SotiriouFevronia Angelatou
Apr 6, 2006·Learning & Memory·Norman M White, Stephane Gaskin
Apr 25, 2006·The European Journal of Neuroscience·Nathan S PentkowskiRobert J Blanchard
Sep 1, 2007·Behavioural Pharmacology·Elif Engin, Dallas Treit
Jun 30, 2009·Proceedings of the National Academy of Sciences of the United States of America·Hong-Wei DongArthur W Toga
Feb 16, 2010·Neuron·Michael S Fanselow, Hong-Wei Dong

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Citations

Jun 15, 2011·Brain Structure & Function·Michael LoureiroAnne Pereira de Vasconcelos
Aug 27, 2013·Neurobiology of Learning and Memory·Thomas J Gould, Prescott T Leach
Nov 29, 2013·Frontiers in Biology·Adalto PontesWenhui Hu
Sep 27, 2012·Neurobiology of Learning and Memory·Chelcie F HeaneyJefferson W Kinney
Jul 4, 2012·The European Journal of Neuroscience·A B McGeachieY Goda
Feb 4, 2014·Journal of Neuroscience Methods·Tine L Gulbrandsen, Robert J Sutherland
Jan 30, 2015·Frontiers in Behavioral Neuroscience·Judith M ReichelCarsten T Wotjak
May 10, 2016·Neurología : publicación oficial de la Sociedad Española de Neurología·F Hernández-LópezB Bernal-Morales
Jul 5, 2016·Physiology & Behavior·Antonio Francisco GodinhoCaique Aparecido Faria
Oct 2, 2019·Brain and Behavior·Shang Lin Tommy LeeEtan J Markus
May 13, 2021·Neuroscience and Biobehavioral Reviews·Nathan S PentkowskiBenjamin J Clark

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