Inactivation of the ventromedial prefrontal cortex mimics re-emergence of heroin seeking caused by heroin reconditioning

Neuroscience Letters
Jelena Ovari, Francesco Leri

Abstract

The purpose of this study was to investigate the role of the ventromedial prefrontal cortex (vmPFC) in the expression of extinguished heroin seeking as measured by conditioned place preference (CPP) in males Sprague-Dawley rats (n=25). Heroin place conditioning (0.3mg/kg SC x 4 sessions) was followed by a test of preference 24h later, extinction (saline x 4 sessions), heroin reconditioning (saline or 1.0mg/kg x 1 session), and a second test of place preference 24h later. Fifteen minutes prior to this test, rats received intra-vmPFC infusions (bilateral, 0.5 microl/side) of a mixture of GABA(A) (muscimol; 0.03 nmol) and a GABA(B) (baclofen; 0.3 nmol) agonists, or vehicle. As expected on the basis of previous studies, reconditioning with heroin resulted in the re-emergence of a CPP. Importantly, inactivation of the vmPFC produced the same effect in animals that did not receive heroin on the session of reconditioning. These results indicate that the vmPFC modulates expression of extinguished heroin seeking and suggest that prefrontal inhibitory mechanisms are involved in relapse to drug seeking.

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Citations

Jan 18, 2012·Psychopharmacology·Amanda T CampbellFrancesco Leri
Nov 5, 2013·Trends in Pharmacological Sciences·Jamie PetersTaco J De Vries
Nov 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Haowei ShenPeter W Kalivas
Nov 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michel C Van den OeverAugust B Smit
Jan 10, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·George S PortugalJose A Morón
Sep 29, 2011·Cellular and Molecular Life Sciences : CMLS·Nathan J MarchantGavan P McNally
Oct 2, 2009·Peptides·Richard J Bodnar
Dec 23, 2014·Brain Research·David E MoormanGary Aston-Jones
Feb 11, 2012·The European Journal of Neuroscience·Ryan T LaLumierePeter W Kalivas
Feb 22, 2012·Behavioural Brain Research·Peter A Groblewski, Christopher L Cunningham
Nov 16, 2010·Behavioural Brain Research·E Zayra MillanGavan P McNally
Sep 29, 2011·Neurobiology of Learning and Memory·Peter A GroblewskiChristopher L Cunningham
Nov 26, 2009·Neuroscience and Biobehavioral Reviews·Michel C Van den OeverTaco J De Vries
Jan 30, 2010·Neuroscience and Biobehavioral Reviews·Karyn M Myers, William A Carlezon
Nov 6, 2018·Psychopharmacology·Wen-Hua ZhangYan-Xue Xue
Oct 31, 2017·Brain Structure & Function·Valeria OlivaGianluca Baldassarre
Apr 26, 2016·Nature Neuroscience·Shannon L Gourley, Jane R Taylor
Apr 29, 2020·Cold Spring Harbor Perspectives in Medicine·Jasper A HeinsbroekJamie Peters
Apr 22, 2009·Learning & Memory·Jamie PetersGregory J Quirk

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