Inactivation of ventral midline thalamus produces selective spatial delayed conditional discrimination impairment in the rat

Hippocampus
Jacqueline R HembrookRobert G Mair

Abstract

The reuniens (Re) and rhomboid (Rh) nuclei are organized to influence activity in distributed limbic networks involving hippocampus and medial prefrontal cortex (mPFC). To elucidate the role of these nuclei in spatial memory we inactivated Re and Rh in rats with the GABA(A) agonist muscimol and compared effects on two spatial delayed conditional discriminations: delayed nonmatching to position (DNMTP) and varying choice radial maze delayed nonmatching (VC-DNM). DNMTP is trained in operant chambers and requires rats to choose between the same two levers on all trials. VC-DNM is trained in automated radial mazes and requires rats to choose between two arms, randomly selected from eight alternatives on each trial. DNMTP is affected by hippocampal and mPFC lesions while VC-DNM is affected by hippocampal, but not mPFC lesions (Porter et al. (2000) Behav Brain Res 109:69-81). We found evidence of a localized (low dose) effect of ReRh inactivation on DNMTP but not VC-DNM. This was confirmed by comparison with muscimol injections in an anatomical control site. These results are consistent with evidence that Re and Rh affect measures of spatial working memory that depend on interactions between hippocampus and mPFC, but not measures tha...Continue Reading

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Citations

Jan 25, 2012·Brain Structure & Function·Judy A PrasadYogita Chudasama
Aug 30, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Pia-Kelsey O'NeillTorfi Sigurdsson
Dec 24, 2015·Frontiers in Systems Neuroscience·Jingji Jin, Stephen Maren
Sep 24, 2015·Neurobiology of Learning and Memory·Dylan M LayfieldAmy L Griffin
Sep 13, 2013·Progress in Neurobiology·Jean-Christophe CasselRobert P Vertes
Dec 3, 2014·Neuroscience and Biobehavioral Reviews·Anne Pereira de Vasconcelos, Jean-Christophe Cassel
Jan 24, 2015·Neuroscience and Biobehavioral Reviews·Robert P VertesWalter B Hoover
Apr 11, 2017·Neurobiology of Learning and Memory·Mohamad AliAnne Pereira de Vasconcelos
Dec 23, 2016·Brain Structure & Function·M J Dolleman-van der WeelM P Witter
Jan 12, 2019·The European Journal of Neuroscience·Mathias L MathiasenJohn P Aggleton
Nov 14, 2019·The Journal of Comparative Neurology·Niklas ScheelJohanne G de Mooij-van Malsen
Oct 31, 2018·Nature Communications·Karthik R RamanathanStephen Maren
May 10, 2017·Neuroscience Research·Hiroshi T Ito
Apr 27, 2021·Frontiers in Behavioral Neuroscience·Robert G MairBrett M Gibson
Jul 5, 2021·Neuroscience and Biobehavioral Reviews·Amy L Griffin
Oct 15, 2021·ELife·Jennifer C Robinson, Mark P Brandon
Nov 30, 2021·Hippocampus·Lucas C S Tavares, Adriano B L Tort

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