Inactivation of viruses in platelet and plasma products using a riboflavin-and-UV-based photochemical treatment

Transfusion
Shawn D KeilRaymond P Goodrich

Abstract

Multilayered blood safety programs reduce the risk of transfusion-transmitted diseases; however, there remains a risk of window period transmission of screened viruses and transmission of unscreened and emerging viruses from asymptomatic donors. To reduce this risk, a riboflavin-and-UV-light-based pathogen reduction process was evaluated against eight viral agents. Riboflavin and UV light was evaluated against the following eight viral agents: encephalomyocarditis virus (EMC), hepatitis A virus (HAV), hepatitis C virus (HCV), influenza A (FLUAV), La Crosse virus (LACV), pseudorabies virus (PRV), sindbis virus (SINV), and vesicular stomatitis virus (VSV). Before treatment, a sample was removed to determine the product's initial viral load. After treatment the product's viral load was reevaluated and the log reduction was calculated. Virus reduction after treatment with riboflavin and UV light is equivalent in platelet (PLT) and plasma units, as demonstrated by a 3.2-log reduction of EMC in plasma, PLTs, and PLT additive solution containing 35% plasma. Additionally, the following viral reductions values were observed: HAV 1.8 log, HCV at least 4.1 log, FLUAV at least 5.0 log, LACV at least 3.5 log, PRV 2.5 log, SINV 3.2 log, and ...Continue Reading

References

Dec 21, 2006·Transfusion·Susan P MontgomeryUNKNOWN 2003 West Nile Virus Transfusion-Associated Transmission Investigation Team
Oct 24, 2007·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Lisa J CardoRaymond Goodrich
Dec 3, 2009·Vox Sanguinis·L R Petersen, M P Busch
Apr 9, 2010·Transfusion·Raymond P GoodrichMichael Busch
Sep 14, 2010·International Journal of Antimicrobial Agents·Alfonso Guzman, Raul E Istúriz
May 28, 2011·Blood·Geralyn M MenySusan L Stramer
Jun 8, 2012·Paediatrics and International Child Health·Annelies Wilder-Smith
Aug 9, 2013·MMWR. Morbidity and Mortality Weekly Report·UNKNOWN Centers for Disease Control and Prevention (CDC)
Jul 22, 2014·Photochemistry and Photobiology·Janna M MundtRaymond P Goodrich

❮ Previous
Next ❯

Citations

Sep 9, 2015·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Alesia KaplanMaria Luisa Antelo
Apr 27, 2016·Hematology/oncology Clinics of North America·William J Savage
Jan 23, 2018·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Apr 11, 2018·Transfusion·Aaron A R Tobian, Heather A Hume
Oct 22, 2016·Vox Sanguinis·H M FaddyD C Marks
Jun 23, 2018·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Jun 3, 2021·Journal of Clinical Medicine·Annina CapraruBehrouz Mansouri Taleghani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.