Abstract
Multilayered blood safety programs reduce the risk of transfusion-transmitted diseases; however, there remains a risk of window period transmission of screened viruses and transmission of unscreened and emerging viruses from asymptomatic donors. To reduce this risk, a riboflavin-and-UV-light-based pathogen reduction process was evaluated against eight viral agents. Riboflavin and UV light was evaluated against the following eight viral agents: encephalomyocarditis virus (EMC), hepatitis A virus (HAV), hepatitis C virus (HCV), influenza A (FLUAV), La Crosse virus (LACV), pseudorabies virus (PRV), sindbis virus (SINV), and vesicular stomatitis virus (VSV). Before treatment, a sample was removed to determine the product's initial viral load. After treatment the product's viral load was reevaluated and the log reduction was calculated. Virus reduction after treatment with riboflavin and UV light is equivalent in platelet (PLT) and plasma units, as demonstrated by a 3.2-log reduction of EMC in plasma, PLTs, and PLT additive solution containing 35% plasma. Additionally, the following viral reductions values were observed: HAV 1.8 log, HCV at least 4.1 log, FLUAV at least 5.0 log, LACV at least 3.5 log, PRV 2.5 log, SINV 3.2 log, and ...Continue Reading
References
May 26, 2004·Transfusion·Patrick H RuaneRaymond P Goodrich
Jan 25, 2006·Vox Sanguinis·L J CardoR Goodrich
Dec 21, 2006·Transfusion·Susan P MontgomeryUNKNOWN 2003 West Nile Virus Transfusion-Associated Transmission Investigation Team
Feb 17, 2007·Transfusion·Francisco RentasRaymond Goodrich
Oct 24, 2007·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Lisa J CardoRaymond Goodrich
Nov 15, 2007·PloS One·Marie VazeilleAnna-Bella Failloux
Nov 13, 2008·Transfusion·Azzedine AssalPhilippe De Micco
Mar 27, 2009·Transfusion·Raymond P GoodrichShawn D Keil
Dec 3, 2009·Vox Sanguinis·L R Petersen, M P Busch
Dec 25, 2009·Transfusion·Laura TonnettiDavid A Leiby
Apr 9, 2010·Transfusion·Raymond P GoodrichMichael Busch
May 26, 2010·Transfusion·Brian CusterRebecca Havlir Martinez
Aug 17, 2010·Transfusion·Jos WeustenNico Lelie
Sep 14, 2010·International Journal of Antimicrobial Agents·Alfonso Guzman, Raul E Istúriz
Sep 17, 2010·Journal of Virology·François HelleJean Dubuisson
May 28, 2011·Blood·Geralyn M MenySusan L Stramer
Sep 22, 2011·Vox Sanguinis·W K RothH W Reesink
Feb 1, 2012·Vox Sanguinis·S F O'BrienJ-P Allain
May 26, 2012·Transfusion·Dana L VanlandinghamStephen Higgs
Jun 8, 2012·Paediatrics and International Child Health·Annelies Wilder-Smith
Jan 5, 2013·The Journal of General Virology·Carole FournierSandrine Castelain
Jan 17, 2013·Transfusion·Shawn D KeilRaymond P Goodrich
Aug 9, 2013·MMWR. Morbidity and Mortality Weekly Report·UNKNOWN Centers for Disease Control and Prevention (CDC)
Mar 4, 2014·PloS One·Shahera BanuShilu Tong
May 23, 2014·Transfusion·Takashi OwadaKenji Tadokoro
Jul 22, 2014·Photochemistry and Photobiology·Janna M MundtRaymond P Goodrich
Dec 3, 2014·Transfusion·Shawn D KeilChristopher D Hillyer
Citations
Dec 9, 2015·Transfusion·Christopher A TormeyJeanne E Hendrickson
Mar 24, 2016·Transfusion·Andrew P CapRaymond P Goodrich
Mar 11, 2015·Transfusion·Pieter F van der MeerDirk de Korte
Sep 9, 2015·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Alesia KaplanMaria Luisa Antelo
Apr 27, 2016·Hematology/oncology Clinics of North America·William J Savage
Jan 29, 2016·BMJ Open·Paula F YpmaUNKNOWN PREPAReS Study Group
Jul 23, 2016·Transfusion·Christa Klein-BosgoedDana V Devine
Nov 3, 2016·Transfusion·Shawn D KeilSusanne Marschner
Mar 20, 2018·Platelets·Vishal SalunkheLaura Gutiérrez
Feb 7, 2018·Transfusion·Elissa K Butler, Jeffrey McCullough
Jan 23, 2018·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Mar 27, 2019·Transfusion·Lassina BarroThierry Burnouf
Apr 21, 2020·Vox Sanguinis·Shawn D KeilRichard Bowen
Sep 1, 2020·Transfusion·Yundi YinZhong Liu
Feb 23, 2019·PloS One·Elena BlázquezJavier Polo
Jul 16, 2019·British Journal of Haematology·Paolo Rebulla
Jun 6, 2018·Frontiers in Medicine·Peter SchubertDana V Devine
Apr 11, 2018·Transfusion·Aaron A R Tobian, Heather A Hume
Nov 2, 2019·Journal of Biomedical Science·Ouada NebieThierry Burnouf
Oct 22, 2016·Vox Sanguinis·H M FaddyD C Marks
Jun 23, 2018·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Sep 30, 2018·Transfusion·Ute GravemannAxel Seltsam
Nov 22, 2020·Transfusion·Qinati FeyissaJaroslav G Vostal
Mar 14, 2020·Photodiagnosis and Photodynamic Therapy·Fei XuJaroslav G Vostal
Jun 3, 2021·Journal of Clinical Medicine·Annina CapraruBehrouz Mansouri Taleghani
Jul 17, 2021·Transfusion·Turid Helen Felli LundeTor Audun Hervig