Inactivity and exercise training differentially regulate abundance of Na+ -K+ -ATPase in human skeletal muscle

Journal of Applied Physiology
V L WyckelsmaM J McKenna

Abstract

Physical inactivity is a global health risk that can be addressed through application of exercise training suitable for an individual's health and age. People's willingness to participate in physical activity is often limited by an initially poor physical capability and early onset of fatigue. One factor associated with muscle fatigue during intense contractions is an inexcitability of skeletal muscle cells, reflecting impaired transmembrane Na+/K+ exchange and membrane depolarization, which are regulated via the transmembranous protein Na+-K+-ATPase (NKA). This short review focuses on the plasticity of NKA in skeletal muscle in humans after periods of altered usage, exploring NKA upregulation with exercise training and downregulation with physical inactivity. In human skeletal muscle, the NKA content quantified by [3H]ouabain binding site content shows robust, yet tightly constrained, upregulation of 8-22% with physical training, across a broad range of exercise training types. Muscle NKA content in humans undergoes extensive downregulation with injury that involves substantial muscular inactivity. Surprisingly, however, no reduction in NKA content was found in the single study that investigated short-term disuse. Despite clea...Continue Reading

References

Nov 1, 1992·Journal of Applied Physiology·A D LeBlancE Spector
Oct 1, 1992·International Journal of Sports Medicine·B D Levine, J Stray-Gundersen
Feb 1, 1986·Muscle & Nerve·L Edström, L Grimby
Sep 11, 1986·Biochimica Et Biophysica Acta·K KjeldsenT Clausen
Oct 1, 1984·Scandinavian Journal of Clinical and Laboratory Investigation·A NørgaardT Clausen
Feb 1, 1982·Biochemical Society Transactions·J Gliemann
Apr 1, 1995·Journal of Molecular and Cellular Cardiology·M I Lindinger
Apr 1, 1995·Journal of Molecular and Cellular Cardiology·M J McKenna
Jun 1, 1993·The American Journal of Physiology·H J GreenD Ranney
Jan 1, 1995·European Journal of Applied Physiology and Occupational Physiology·E JebensO M Sejersted
May 1, 1997·The American Journal of Physiology·F EvertsenK Nicolaysen
Nov 14, 1998·The American Journal of Physiology·G Blanco, R W Mercer
May 8, 1999·Journal of Applied Physiology·H GreenN L Melissa
Feb 5, 2000·Journal of Applied Physiology·H GreenD McKenzie
Oct 4, 2000·Physiological Reviews·O M Sejersted, G Sjøgaard
Jun 8, 2001·European Journal of Applied Physiology·J I MedbøP Gramvik
Aug 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S HeJ B Lingrel
Sep 8, 2001·American Journal of Physiology. Cell Physiology·J WangR A Farley
Nov 20, 2001·Pflügers Archiv : European journal of physiology·C JuelT Wulff
Dec 12, 2001·Acta Physiologica Scandinavica·O Hansen
Jan 5, 2002·Journal of Bioenergetics and Biomembranes·K Geering
Feb 13, 2002·The Journal of Orthopaedic and Sports Physical Therapy·Richard K Shields
May 24, 2003·Annals of the New York Academy of Sciences·Käthi GeeringGilles Crambert
Jun 14, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yuk-Chow NgRussell L Moore
Sep 25, 2003·Physiological Reviews·Torben Clausen

❮ Previous
Next ❯

Citations

Apr 16, 2020·American Journal of Physiology. Cell Physiology·Violetta V KravtsovaIgor I Krivoi
Jun 6, 2020·European Journal of Applied Physiology·Muath M AltarawnehMichael J McKenna
Jan 5, 2021·European Journal of Applied Physiology·Michael I Lindinger, Simeon P Cairns
Jan 6, 2021·Journal of Muscle Research and Cell Motility·Sergej PirkmajerAlexander V Chibalin
Aug 28, 2021·Animals : an Open Access Journal From MDPI·Muhammed Elayadeth-MeethalMichael R F Lee

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
coimmunoprecipitation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.