Inactivity-induced modulation of Hsp20 and Hsp25 content in rat hindlimb muscles

Muscle & Nerve
Kimberly A HueyRoland R Roy

Abstract

Denervation decreases small heat shock protein (HSP) content in the rat soleus muscle; however, it is unknown whether this change is due to inactivity or absence of a nerve-muscle connection. Spinal cord isolation (SI) is a model of inactivity with an intact neuromuscular connection. After 7 days of SI, Hsp20 and Hsp25 levels in the soleus, plantaris, and adductor longus muscles were lower than in control rats, whereas Hsp20 was unchanged and Hsp25 increased in the tibialis anterior. The results for the soleus indicate that these small HSPs respond to inactivity and that this response is not influenced by neural activity-independent factors. Furthermore, the data indicate that these HSPs are impacted to a greater degree in muscles that are predominantly slow or have an antigravity function than in flexor muscles. Understanding the regulation of these HSPs during chronic reductions in neuromuscular activity may have valuable applications for conditions such as spinal cord injury.

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Citations

Oct 19, 2007·European Journal of Applied Physiology·Chad TouchberryPhilip Gallagher
Jul 2, 2009·Cell Stress & Chaperones·Catherine M DreizaColleen M Brophy
Oct 18, 2011·Cell Stress & Chaperones·Evgeny V MymrikovNikolai B Gusev
Dec 23, 2008·Biochimica Et Biophysica Acta·Olesya V BukachNikolai B Gusev
Jun 27, 2008·Pharmacology & Therapeutics·Sonemany SalinthoneWilliam T Gerthoffer
Apr 17, 2007·The Journal of Nutritional Biochemistry·Arthur GriderAngus G Scrimgeour
Jun 18, 2005·Muscle & Nerve·Robert N Nishimura, Frank R Sharp
Sep 30, 2010·Muscle & Nerve·Benjamin M Meador, Kimberly A Huey
Oct 15, 2011·Journal of Applied Physiology·Fuminori KawanoYoshinobu Ohira
Oct 21, 2011·Physiological Reviews·Evgeny V MymrikovNikolai B Gusev
Dec 22, 2006·American Journal of Physiology. Cell Physiology·F KawanoY Ohira
Aug 14, 2019·Physiology and Molecular Biology of Plants : an International Journal of Functional Plant Biology·Issam NouairiHaythem Mhadhbi
May 29, 2012·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Jian Chen, Zhi Min Yang

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