Inadequate Production of H2 by Gut Microbiota and Parkinson Disease

Trends in Endocrinology and Metabolism : TEM
Sergej M Ostojic

Abstract

Dysbiosis of the gut flora accompanies Parkinson disease (PD), yet no specific cause-effect link has been identified so far. The gut microbiota produce molecular hydrogen (H2), a ubiquitous molecule recently recognized as a biologically active gas with antioxidant, antiapoptotic, anti-inflammatory, cytoprotective, and signaling properties. Here, we discuss an idea that an impaired production of endogenous H2 by intestinal microbiota might play a role in PD pathogenesis, with supplemental H2 debated as a possible therapy for this progressive neurodegenerative disease.

Citations

Aug 2, 2018·Applied Microbiology and Biotechnology·Muhammad Shahid Riaz RajokaJunling Shi
Dec 20, 2018·Gut Microbes·Nick W SmithWarren C McNabb
May 16, 2019·Neurotoxicity Research·Michelle L GarcezGilles J Guillemin
Aug 27, 2019·Frontiers in Oncology·Sai LiKang Peng
Jan 10, 2019·Oxidative Medicine and Cellular Longevity·Laura DumitrescuBogdan Ovidiu Popescu
May 24, 2020·Alimentary Pharmacology & Therapeutics·Sergej M Ostojic
Nov 21, 2019·Movement Disorders Clinical Practice·Clara BullichPaula Perez-Pardo
Jul 1, 2020·Frontiers in Pharmacology·Yaxing ZhangHongzhi Yang
Oct 15, 2019·Journal of Parkinson's Disease·Sebastiaan P van Kessel, Sahar El Aidy
Oct 21, 2020·Neuroscience Bulletin·Wei ChenShu-Cun Qin
Jan 6, 2021·Neurochemical Research·Charul RajputMahendra Pratap Singh
Apr 28, 2021·Ageing Research Reviews·Shen-Yuan ZhengHan-Deng Liu
Jun 26, 2021·Ageing Research Reviews·Mario F Munoz-PintoSandra M Cardoso
Sep 14, 2021·Frontiers in Neuroscience·Amaryllis E HillPhilip W J Burnet
Oct 16, 2021·Frontiers in Microbiology·Liangwei MaoPuqing Wang
Dec 15, 2020·Current Pharmaceutical Design·Svetlana N Radyuk

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