Inadequate target volume delineation and local-regional recurrence after intensity-modulated radiotherapy for human papillomavirus-positive oropharynx cancer

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Allen M ChenMinsong Cao

Abstract

To perform a spatial analysis of local-regional recurrences, in relation to quantitative dose distribution, among patients treated by intensity-modulated radiotherapy (IMRT) for human papillomavirus (HPV)-positive oropharyngeal cancer. The records of 107 consecutive patients who presented for consideration of re-irradiation for local-regional recurrent disease occurring in a previously irradiated field were reviewed. The original IMRT plans were retrieved for those with HPV-positive disease originating from the oropharynx, and deformable image registration was used to fuse the magnetic resonance imaging (MRI) and positron emission tomography (PET) scans obtained at recurrence to the pre-treatment planning computed tomography (CT) dataset. The recurrent tumor volume (Vrecur) was subsequently identified on axial imaging, and the dose of radiation received by Vrecur was then calculated and analyzed using dose-volume histograms. A total of 83 recurrent lesions occurring in 50 oropharyngeal cancer patients were HPV-positive and met inclusion criteria. Using PET-defined Vrecur, thirty-three lesions were classified as in-field recurrences (40%), 35 were marginal misses (41%), and 15 were true misses (18%). Using the MRI-defined Vrecur...Continue Reading

Citations

May 18, 2019·American Society of Clinical Oncology Educational Book·Lori J WirthJeremy Richmon
May 20, 2018·Radiation Oncology·Michael P JonesMichael Jameson
Jan 16, 2020·Cancers of the Head & Neck·Howard E Morgan, David J Sher
Aug 18, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Mette SaksøJens Overgaard
Oct 27, 2020·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Naohiro SakashitaTeruki Teshima
Mar 6, 2021·Clinical and Translational Radiation Oncology·Linda NissiHeikki Minn
Nov 2, 2019·Hematology/oncology Clinics of North America·Sonja StiebClifton David Fuller
Jul 17, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Xiufang QiuChuanben Chen

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