PMID: 602935Jan 1, 1977Paper

Inappropriate erythropoietin secretion in polycythemia vera

American Journal of Hematology
G ChikkappaE D Zanjani

Abstract

A patient with classical polycythemia vera (PV) was found to have an inappropriately elevated serum erythropoietin (Ep) level. Investigations did not reveal any lesion or blood abnormality known to be associated with excessive Ep production and erythrocytosis. Sudden withdrawal of blood to reduce the Hb and Hct from 18.5 gm% and 56% to 13.6 gm% and 41.5%, respectively, resulted in an increment of serum Ep to abnormal level. With iron treatment there was a brisk return of Hb and Hct to prebleeding levels which was associated with reduction in the serum Ep. The inverse relationship between the Ep and Hb or Hct is inconsistent with the presence of excessive Ep-producing lesion. These results suggested that the threshold for Ep secretion from normal Ep-secreting tissue to Hb and Hct levels is set at an abnormal level. This patient's marrow cells when cultured in vitro in the absence of Ep, unlike other PV patients' (except one) marrow cells, did not grow erythroid colonies. In the presence of Ep, however, the colonies comparable to those formed from normal marrow cultures were obtained. These results suggested that his marrow erythropoietic cells were neither Ep independent nor Ep-hyperresponsive, as has been suggested by some inve...Continue Reading

References

May 1, 1977·The Journal of Clinical Investigation·E D ZanjaniL R Wasserman
Mar 15, 1975·International Journal of Cancer. Journal International Du Cancer·S K Liao, A A Axelrad
Dec 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·H BurlingtonE D Zanjani
Mar 29, 1968·Annals of the New York Academy of Sciences·T A WaldmannR L Swarm
Mar 29, 1968·Annals of the New York Academy of Sciences·J W Adamson, C A Finch
Mar 29, 1968·Annals of the New York Academy of Sciences·J F CamiscoliA S Gordon
Nov 1, 1966·The Medical Clinics of North America·L R Wasserman, H S Gilbert

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Citations

Jan 1, 1976·Biulleten' eksperimental'noĭ biologii i meditsiny·E A ZherbinA S Sysoev
Mar 24, 2007·Experimental Hematology·Nicholas DainiakLudwig Feinendegen
Feb 1, 1983·American Journal of Hematology·C M Richman, J D Rowley

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