PMID: 8944605Nov 1, 1996Paper

Inappropriate phosphate excretion in idiopathic hypercalciuria: the key to a common cause and future treatment?

Journal of Clinical Pathology
C P WilliamsA R De Bolla

Abstract

To present experimental evidence in support of a proposed common cause for absorptive hypercalciuria, renal hypercalciuria, renal phosphate leak and enhancement of 1,25-(OH)2-vitamin D concentrations in patients presenting with renal stone disease; and to suggest further investigation with a view to new management. An oral calcium loading test was administered to 15 patients with renal stones and 10 normal controls in the fasting state: urine and blood were collected hourly. After the second urine sample, 400 mg calcium dissolved in water was administered orally. Serum calcium, albumin, parathyroid hormone (PTH), and phosphate were measured together with urine calcium clearance and urinary phosphate from which the TmPO4/glomerular filtration rate (GFR) ratio was calculated. Serum 1,25-(OH)2-vitamin D was measured in the first serum sample. In addition, 24 hour urine calcium results were collected retrospectively from the patients' case notes over the previous 18 months. In the basal state, renal stone patients had an overall greater phosphaturia (lower TmPO4/GFR: median 1.72 compared with 2.10 in controls) and increased calcium clearance. Serum corrected calcium and PTH concentrations did not differ between the groups. After ca...Continue Reading

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Citations

Feb 22, 1997·Lancet·R J Alpern, K Sakhaee
Jun 26, 2001·Kidney International·D PriéG Friedlander
Mar 29, 2001·Journal of Clinical Pathology·C P WilliamsA R De Bolla
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