Abstract
The response of the renin-angiotensin system to high and low sodium diets, to standing, and to saralasin infusion was assessed before and after surgical correction of aortic coarctation in a 27-year-old man. The cardiovascular responses to tests of autonomic function were measured. The heart rate responses to the Valsalva manoeuvre and standing were abnormal before operation, and plasma renin levels were high and renin secretion responded poorly to changes in dietary sodium, to standing, and to saralasin. Renin responsiveness and cardiovascular reflexes returned to normal after operation. The results are consistent with the hypothesis that there is a high level of sympathetic efferent activity in coarctation of the aorta and that factors other than increased activity of the renin-angiotensin system may cause high blood pressure.
References
Jul 1, 1979·Clinical Endocrinology·D McGivernD J Warren
Jan 21, 1978·British Medical Journal·D J EwingB F Clarke
Jul 1, 1975·British Heart Journal·A MarkiewiczA Cicha
Oct 1, 1975·Clinical Science and Molecular Medicine·P L PadfieldM Tree
Dec 15, 1973·Lancet·D J EwingB F Clarke
Jan 24, 1970·Lancet·D J Warren, T F Ferris
Nov 1, 1969·Circulation·C WerningW Siegenthaler
Dec 1, 1970·American Heart Journal·D F LeonJ J Leonard
Mar 1, 1969·The American Journal of Cardiology·E A AmsterdamR B Hickler
Nov 20, 1965·British Medical Journal·J J BrownJ I Robertson
Jul 1, 1966·The American Journal of Cardiology·A B Levin
Jan 1, 1967·British Heart Journal·P T Pickens
Jan 1, 1956·Scandinavian Journal of Clinical and Laboratory Investigation·H BUCHTL WERKO
Dec 1, 1950·The American Journal of Medicine·J S HARRISW DEMARIA
Mar 1, 1941·The Journal of Clinical Investigation·M FriedmanW Picard
Sep 1, 1941·The Journal of Clinical Investigation·J M Steele
Jul 31, 1940·The Journal of Experimental Medicine·K G Kohlstaedt, I H Page