Sep 1, 1977

Inappropriate secretion of antidiuretic hormone in children with bacterial meningitis

The American Journal of Clinical Nutrition
R D Feigin, S Kaplan

Abstract

A prospective study of bacterial meningitis in children was initiated two years ago. Serum sodium concentrations below 135 MEQ/liter were noted on admission in 72 of 124 (58.1 %) of patients enrolled in the study protocol. Low initial serum sodium concentration and prolonged depression in serum sodium despite fluid restriction correlated significanly (P less than 0.001 to 0.01) with the presence of neurologic sequelae of the disease. Inappropriate secretion of antidiuretic hormone as the cause of these electrolyte changes could be inferred by indirect measurement of serum and urine solute and volume data and was specifically documented, in patients enrolled most recently, by specific radioimmunoassay of antidiuretic hormone.

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Mentioned in this Paper

Urine
Electrolytes
Pitressin
Antidiuretic Hormone Measurement
Water-Electrolyte Imbalance
Sodium
Electrolyte [EPC]
AVP
Serum Sodium Measurement
Radioimmunoassay

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