PMID: 7023312Sep 1, 1981Paper

Inappropriate secretion of thyroid-stimulating hormone

Annals of Internal Medicine

Abstract

Recent studies have provided major new insights into the syndromes of inappropriate secretion of thyroid-stimulating hormone (TSH), a heterogeneous group of disorders in which patients show inappropriately elevated levels of serum immunoactive TSH in the presence of elevated free thyroid hormone levels. Certain of these patients appear to have a non-neoplastic disorder associated with variable degrees of pituitary and peripheral resistance to the action of thyroid hormone, whereas others harbor a tumor of pituitary thyrotropic cells. Measurement of free serum alpha subunit has proved valuable in differentiating these disorders, showing normal alpha concentration and alpha-to-TSH ratios in the non-neoplastic and highly elevated values in the neoplastic disorders. All these syndromes appear unrelated to Graves' disease because thyroid-binding and thyroid-stimulating antibodies are usually absent. Some of these patients also have abnormal metabolism of thyroid hormones. Although the pathogenesis of these syndromes remains to be elucidated, increased recognition and study of these patients should provide fundamental insights into the regulation of TSH secretion as well as the action of thyroid hormone.

Citations

Jan 1, 1982·Virchows Archiv. A, Pathological Anatomy and Histology·K KovacsM H Weiss
Sep 1, 1985·Irish Journal of Medical Science·J P McCann, J K Nelson
Sep 1, 1986·The American Journal of Medicine·G A BrentG D Braunstein
Jun 22, 1985·Lancet
Apr 20, 1999·Endocrinology and Metabolism Clinics of North America·M E Shomali, L Katznelson
Apr 16, 1998·Endocrinology and Metabolism Clinics of North America·M T McDermott, E C Ridgway
Aug 1, 1988·Baillière's Clinical Endocrinology and Metabolism·P Beck-Peccoz, G Medri
Jan 1, 1994·Thyroid : Official Journal of the American Thyroid Association·S Refetoff
Aug 1, 1996·Thyroid : Official Journal of the American Thyroid Association·D S Cooper, B M Wenig
Feb 1, 1994·Acta Paediatrica Japonica; Overseas Edition·S Refetoff
Feb 1, 1996·Australian and New Zealand Journal of Medicine·M K StilesB Chatterton
Dec 1, 1992·Acta Paediatrica·A AvramidesA Vyzantiadis
Feb 11, 1999·Journal of Endocrinological Investigation·P Iglesias, J J Díez
Dec 1, 1985·Journal of Endocrinological Investigation·H CavaliereI A Kourides
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A SakuraiL J DeGroot
Nov 1, 1987·The Journal of Clinical Investigation·J L JamesonJ F Habener
Mar 1, 1996·The Journal of Clinical Investigation·G Medeiros-NetoF E Wondisford
Feb 1, 1985·The American Journal of the Medical Sciences·J E Griffin
May 4, 2007·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Sheng-Fong KuoJen-Der Lin
Feb 1, 1990·Clinical Biochemistry·N Amino
May 1, 1982·Metabolism: Clinical and Experimental·D S CooperE C Ridgway
Aug 1, 1989·Disease-a-month : DM·J E Bethune
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G De RosaC Carrozza
Apr 1, 1986·Surgical Neurology·F GrisoliR Nayak
Apr 1, 1993·The American Journal of Medicine·M T McDermott, E C Ridgway
Apr 1, 1985·Australian and New Zealand Journal of Medicine·J R Stockigt, J W Barlow
Jul 1, 1983·Clinical Endocrinology·H A KellettA D Toft
Dec 1, 1988·Australian and New Zealand Journal of Medicine·P J Fuller
Jan 1, 1992·The American Journal of Medicine·A G WynneE Horvath

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