Inappropriately high circulating and intrarenal angiotensin II levels during dietary salt loading exacerbate hypertension in Cyp1a1-Ren-2 transgenic rats

Journal of Hypertension
Zuzana HuskováLudêk Cervenka

Abstract

We evaluated the effects of salt restriction and of increasing dietary salt loading on blood pressure and the renin-angiotensin system in transgenic rats with inducible hypertension. Hypertension was induced in Cyp1a1-Ren-2 rats through dietary administration of the natural xenobiotic indole-3-carbinol (0.3%), which activates the renin gene. Rats were fed either a normal-salt diet (0.6% NaCl), three different high-salt diets (2, 4 and 8% NaCl) or a low-salt diet (<0.04% NaCl). Blood pressure was monitored by radiotelemetry. Angiotensin II (ANG II) levels were determined by radioimmunoassay. Induction of the renin gene by administration of indole-3-carbinol resulted in normal-salt diet fed animals in the development of severe hypertension that was accompanied by marked increases in plasma and kidney ANG II levels. Feeding the low-salt diet substantially attenuated the development of hypertension. Treatment with the 2 and 4% high-salt diet did not worsen the course of hypertension and did not alter ANG II levels when compared with rats on the normal salt diet. Feeding the 8% high-salt diet exacerbated the course of hypertension and was associated with further strong increases in plasma and kidney ANG II levels. Our results demons...Continue Reading

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Citations

Feb 25, 2011·Journal of Hypertension·Dinko SusicL Gabriel Navar
Jan 30, 2014·Clinical and Experimental Pharmacology & Physiology·Petr KujalLudek Červenka
Oct 26, 2011·Journal of Hypertension·Bart F J HeijnenHarry A J Struijker-Boudier
Dec 6, 2016·The American Journal of the Medical Sciences·Šárka JíchováLuděk Červenka

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