Inborn errors of anti-viral interferon immunity in humans.

Current Opinion in Virology
Vanessa Sancho-ShimizuJean-Laurent Casanova

Abstract

The three types of interferon (IFNs) are essential for immunity against at least some viruses in the mouse model of experimental infections, type I IFNs displaying the broadest and strongest anti-viral activity. Consistently, human genetic studies have shown that type II IFN is largely redundant for immunity against viruses in the course of natural infections. The precise contributions of human type I and III IFNs remain undefined. However, various inborn errors of anti-viral IFN immunity have been described, which can result in either broad or narrow immunological and viral phenotypes. The broad disorders impair the response to (STAT1, TYK2) or the production of at least type I and type III IFNs following multiple stimuli (NEMO), resulting in multiple viral infections at various sites, including herpes simplex encephalitis (HSE). The narrow disorders impair exclusively (TLR3) or mostly (UNC-93B, TRIF, TRAF3) the TLR3-dependent induction of type I and III IFNs, leading to HSE in apparently otherwise healthy individuals. These recent discoveries highlight the importance of human type I and III IFNs in protective immunity against viruses, including the TLR3-IFN pathway in protection against HSE.

References

Feb 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R J Whitley, F Lakeman
Dec 1, 1995·Immunological Reviews·M F van den BroekM Aguet
Oct 6, 1998·Annual Review of Biochemistry·G R StarkR D Schreiber
Jul 18, 2000·Journal of Medical Virology·F NajioullahB Lina
Apr 5, 2002·Current Treatment Options in Neurology·Richard J. Whitley
Dec 7, 2002·Nature Immunology·Paul SheppardKevin M Klucher
Mar 15, 2003·Science·Capucine PicardJean-Laurent Casanova
Sep 12, 1957·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A ISAACS, J LINDENMANN
Nov 18, 2004·Immunological Reviews·Sidney PestkaMark R Walter
Jan 22, 2005·Immunological Reviews·Cheng-Lung KuJean-Laurent Casanova
Sep 29, 2005·Journal of Virology·Christophe PréhaudMonique Lafon
Feb 25, 2006·Cell·Shizuo AkiraOsamu Takeuchi
Jul 5, 2006·The Journal of Experimental Medicine·Orchidée Filipe-SantosJean-Laurent Casanova
Aug 29, 2006·PLoS Genetics·Ariane ChapgierJean-Laurent Casanova
Sep 7, 2006·Journal of Endotoxin Research·Eric M PietrasGenhong Cheng
Sep 16, 2006·Science·Armanda CasrougeJean-Laurent Casanova
Sep 19, 2006·Immunity·Anette H H van Boxel-DezaireGeorge R Stark
Mar 21, 2007·Biochimie·Gilles Uzé, Danièle Monneron
Jun 15, 2007·Biochimie·Emmanuelle JouanguyJean-Laurent Casanova
Aug 4, 2007·Science·Jean-Laurent Casanova, Laurent Abel
Sep 18, 2007·Science·Shen-Ying ZhangJean-Laurent Casanova
Nov 6, 2007·Immunological Reviews·Shen-Ying ZhangJean-Laurent Casanova
Nov 9, 2007·Current Opinion in Allergy and Clinical Immunology·Vanessa Sancho-ShimizuJean-Laurent Casanova
Aug 2, 2008·Science·Horst von BernuthJean-Laurent Casanova
Jan 6, 2009·Immunological Reviews·Shin-Ichiroh Saitoh, Kensuke Miyake
May 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Wenxiang SunZhengfan Jiang
May 14, 2009·The Journal of Clinical Investigation·Ariane ChapgierJean-Laurent Casanova
May 20, 2009·Clinical Reviews in Allergy & Immunology·Jennifer HeimallSteven M Holland
Aug 5, 2009·Cytokine & Growth Factor Reviews·Pierre GéninAhmet Civas

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Citations

Sep 10, 2013·Trends in Immunology·Haina Shin, Akiko Iwasaki
Mar 20, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yuval ItanJean-Laurent Casanova
Aug 2, 2012·The Journal of Experimental Medicine·Melina HermanJean-Laurent Casanova
Jul 19, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A VenkatesanUNKNOWN International Encephalitis Consortium
Jun 4, 2013·Annual Review of Genomics and Human Genetics·Jean-Laurent Casanova, Laurent Abel
Mar 5, 2013·PLoS Pathogens·Eric Delwart
Mar 19, 2013·Viruses·Frédéric SorgeloosThomas Michiels
Mar 13, 2014·Journal of Clinical Immunology·John RoutesTroy Torgerson
Aug 2, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Shreeram C Nallar, Dhan V Kalvakolanu
Jul 29, 2015·The Journal of Experimental Medicine·Line Lykke AndersenTrine H Mogensen
Feb 5, 2013·The Journal of Allergy and Clinical Immunology·Nima ParvanehMary Ellen Conley
Jan 8, 2013·Current Opinion in Immunology·Shen-Ying ZhangJean-Laurent Casanova
Aug 6, 2013·Immunology·Renzo Perales-Linares, Sonia Navas-Martin
Aug 16, 2012·Journal of Internal Medicine·M G NeteaJ W M van der Meer
Sep 10, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Yael HacohenMing J Lim
Jun 2, 2012·Current Opinion in Immunology·Stephanie Boisson-DupuisJean-Laurent Casanova
May 26, 2015·Frontiers in Immunology·Fabien G LafailleShen-Ying Zhang
Jul 18, 2015·Journal of the Pediatric Infectious Diseases Society·Alasdair BamfordSunil P Pullaperuma
Apr 1, 2014·Cell·Herbert W Virgin
Apr 24, 2012·Immunity·Jean-Laurent CasanovaLuigi D Notarangelo
Jul 24, 2012·Current Opinion in Microbiology·Desa Lilic
Apr 10, 2014·Current Opinion in Virology·John W Schoggins
Oct 9, 2012·The Journal of Allergy and Clinical Immunology·László MaródiJean-Laurent Casanova
Jan 31, 2015·Canadian Journal of Microbiology·Xiuning SunZhijun Liu
Nov 7, 2014·Frontiers in Microbiology·Sammy Bedoui, Marie Greyer
Jun 5, 2016·Pediatric Rheumatology Online Journal·Stefano VolpiMarco Gattorno
Sep 17, 2016·Human Vaccines & Immunotherapeutics·Olga LeplinaElena Chernykh
May 26, 2016·PLoS Pathogens·Cindy S E TanPhilip G Stevenson
Mar 10, 2017·DNA and Cell Biology·Daniel GiraldoRichard Longnecker
Aug 5, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Siva Karthik VaranasiBarry T Rouse
Jun 22, 2018·Nature Reviews. Neurology·Elizabeth WellsUNKNOWN attendees of the International Neuroimmune Meeting
Jul 22, 2016·Journal of Virology·Maitreyi ShivkumarPhilip G Stevenson
Oct 4, 2018·Expert Review of Clinical Immunology·Peter Olbrich, Alexandra F Freeman
Feb 26, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yong ZhangMichael J Holtzman
Dec 22, 2012·Expert Review of Clinical Immunology·Donald C Vinh, Marcel A Behr

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