Inbred mouse strains differ in sensitivity to "popping" behavior elicited by MK-801

Pharmacology, Biochemistry, and Behavior
S I DeutschJ Mastropaolo

Abstract

We examined possible genetic contributions to MK-801-elicited "popping" behavior in mice. MK-801-elicited "popping" behavior may represent a preclinical screening paradigm for identifying novel antipsychotic medications. Specifically, we studied the sensitivity of four inbred strains of mice (BALB/c, C57BL/6, AKR, and DBA/2) to MK-801-elicited "popping" behavior and compared their response to the outbred NIH Swiss strain in which the behavior was first characterized. The BALB/c strain was most sensitive to the elicitation of MK-801 induced popping behavior, whereas the other inbred strains were less sensitive than the outbred strain. The identification of strain differences in MK-801-elicited "popping" behavior suggests an important role for genetic factors in the elicitation of MK-801 "popping" behavior in mice.

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Citations

Jan 19, 2008·Neurotoxicity Research·Yousef Tizabi
Oct 26, 2013·Brain Research Bulletin·Andrew D BensonStephen I Deutsch
Dec 14, 2002·Pharmacology, Biochemistry, and Behavior·Eddie N BillingsleaStephen I Deutsch
Feb 11, 1999·Pharmacology, Biochemistry, and Behavior·S I DeutschJ Mastropaolo
Sep 24, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Philip R CorlettPaul C Fletcher
Mar 15, 2011·Brain Research Bulletin·Luis F JacomeStephen I Deutsch
Aug 5, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Pin-Yu PereraStephen I Deutsch
Jan 22, 2008·Neuroscience and Biobehavioral Reviews·Tamara J PhillipsJeanna M Wheeler
Jul 28, 2007·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Stephen I DeutschJohn Mastropaolo
Sep 2, 2011·Autism Research : Official Journal of the International Society for Autism Research·Luis F JacomeStephen I Deutsch
Mar 19, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jessica A BurketStephen I Deutsch
Feb 24, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jessica A BurketStephen I Deutsch
Jul 8, 2011·The International Journal of Neuropsychopharmacology·Akihiro MouriToshitaka Nabeshima
Dec 25, 2008·Experimental Eye Research·Stuart J McKinnonRobert W Nickells
Aug 2, 2019·Investigative Ophthalmology & Visual Science·Rebecca A BuchananGareth R Howell
Jan 7, 2020·Experimental Neurobiology·Darine Froy N MabungaSe Jin Jeon
Nov 14, 2019·International Journal of Molecular Sciences·Iulia Zoicas, Johannes Kornhuber
Feb 2, 2021·Frontiers in Cellular Neuroscience·Tanya Gandhi, Charles C Lee

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