Inbreeding by environmental interactions affect gene expression in Drosophila melanogaster.

Genetics
Torsten N KristensenV Loeschcke

Abstract

Genomewide gene expression patterns were investigated in inbred and noninbred Drosophila melanogaster lines under benign and stressful (high temperature) environmental conditions in a highly replicated experiment using Affymetrix gene chips. We found that both heat-shock protein and metabolism genes are strongly affected by temperature stress and that genes involved in metabolism are differentially expressed in inbred compared with noninbred lines, and that this effect is accentuated after heat stress exposure. Furthermore we show that inbreeding and temperature stress cause increased between-line variance in gene expression patterns. We conclude that inbreeding and environmental stress both independently and synergistically affect gene expression patterns. Interactions between inbreeding and the environment are often observed at the phenotypic level and our results reveal some of the genes that are involved at the individual gene level. Our observation of several metabolism genes being differentially expressed in inbred lines and more so after exposure to temperature stress, together with lower fitness in the investigated inbred lines, supports the hypothesis that superiority of heterozygous individuals partly derives from inc...Continue Reading

References

Dec 11, 1999·Nucleic Acids Research·M Kanehisa, S Goto
Aug 3, 2001·Genome Research·UNKNOWN Gene Ontology Consortium
May 15, 2002·Current Biology : CB·Scott D PletcherLinda Partridge
Nov 28, 2002·Nature Genetics·Andrew J HollowayDavid D L Bowtell
Nov 28, 2002·Nature Genetics·Gavin MacBeath
Apr 3, 2003·Nature Reviews. Genetics·Suzanne L Rutherford
Oct 2, 2003·Genome Biology·Douglas A HosackRichard A Lempicki
Dec 25, 2003·Bioinformatics·Jelle J GoemanHans C van Houwelingen
May 12, 2004·Proceedings of the National Academy of Sciences of the United States of America·Gary N LandisJohn Tower
Jun 4, 2004·Nature Biotechnology·Zhijin Wu, Rafael A Irizarry
Sep 17, 2004·Nature Reviews. Genetics·Greg Gibson, Ian Dworkin
Jun 10, 2005·Genetics·Torsten Nygaard KristensenVolker Loeschcke
Jul 22, 2005·Journal of Evolutionary Biology·R Bijlsma, V Loeschcke
Jul 22, 2005·Journal of Evolutionary Biology·K S PedersenV Loeschcke
Oct 14, 2005·Biological Reviews of the Cambridge Philosophical Society·Peter A Parsons
Dec 13, 2005·Cell Stress & Chaperones·Jesper G SørensenVolker Loeschcke
May 2, 2006·Statistical Applications in Genetics and Molecular Biology·Gordon K Smyth

❮ Previous
Next ❯

Citations

Dec 13, 2006·Biogerontology·Alejandra C ScannapiecoFabian M Norry
Oct 6, 2011·Heredity·M P García Guerreiro
Jun 5, 2008·Proceedings. Biological Sciences·Torsten N KristensenVolker Loeschcke
Mar 21, 2007·BMC Evolutionary Biology·Hafid LaayouniMauro Santos
Feb 17, 2010·Genetics·Anthony J GreenbergAndrew G Clark
Jul 13, 2011·International Journal of Molecular Sciences·Heather Kirk, Joanna R Freeland
Jul 31, 2014·Heredity·Kristin Franke, Klaus Fischer
Aug 27, 2011·Journal of Insect Physiology·Marie-Pierre ChapuisGregory A Sword
Mar 17, 2010·Trends in Genetics : TIG·N Joop OuborgPhil W Hedrick
Sep 8, 2009·Trends in Ecology & Evolution·Torsten N KristensenVolker Loeschcke
Jul 25, 2009·Conservation Biology : the Journal of the Society for Conservation Biology·Julien F AyrolesKen N Paige
Feb 8, 2008·Conservation Biology : the Journal of the Society for Conservation Biology·Torsten N KristensenAry A Hoffmann
Jul 18, 2008·Journal of Evolutionary Biology·C J VermeulenV Loeschcke
May 16, 2012·Annals of the New York Academy of Sciences·David H ReedTorsten N Kristensen
Jul 7, 2011·Evolution; International Journal of Organic Evolution·Emma VitikainenLiselotte Sundström
Aug 25, 2010·Evolution; International Journal of Organic Evolution·Charles W Fox, David H Reed
Feb 1, 2012·Evolutionary Applications·Francesco AngeloniJoop Ouborg
Jun 12, 2010·Annals of the New York Academy of Sciences·Roosa LeimuN Joop Ouborg
Jun 11, 2015·Heredity·M F SchouT N Kristensen
Jan 25, 2014·Journal of Insect Physiology·Palle JensenTorsten Nygaard Kristensen
May 9, 2018·Evolution; International Journal of Organic Evolution·Mads F SchouTorsten N Kristensen
Oct 17, 2018·Current Zoology·Raïssa Anna de BoerWendt Müller

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.