Inchoate CD8+ T cell responses in neonatal mice permit influenza-induced persistent pulmonary dysfunction.

The Journal of Immunology : Official Journal of the American Association of Immunologists
Dahui YouStephania A Cormier

Abstract

Influenza infection remains a significant cause of pulmonary morbidity and mortality worldwide, with the highest hospitalization and mortality rates occurring in infants and elder adults. The mechanisms inducing this considerable morbidity and mortality are largely unknown. To address this question, we established a neonatal mouse model of influenza infection to test the hypothesis that the immaturity of the neonatal immune system is responsible for the severe pulmonary disease observed in infants. Seven-day-old mice were infected with influenza A virus (H1N1) and allowed to mature. As adults, these mice showed enhanced airway hyperreactivity, chronic pulmonary inflammation, and diffuse emphysematous-type lesions in the lungs. The adaptive immune responses of the neonates were much weaker than those of adults. This insufficiency appeared to be in both magnitude and functionality and was most apparent in the CD8(+) T cell population. To determine the role of neonatal CD8(+) T cells in disease outcome, adult, naive CD8(+) T cells were adoptively transferred into neonates before infection. Neonatal mice receiving the adult CD8(+) T cells had significantly lower pulmonary viral titers and greatly improved pulmonary function as adul...Continue Reading

References

Oct 1, 1977·The American Review of Respiratory Disease·L R Laraya-CuasayN N Huang
Jan 1, 1996·Epidemiologic Reviews·W P Glezen
Dec 31, 1997·The Pediatric Infectious Disease Journal·W P GlezenP A Piedra
Feb 12, 1998·The Journal of Experimental Medicine·M B Graham, T J Braciale
Jun 24, 1999·Immunology Today·B Adkins
Feb 29, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·B AdkinsR Perez
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·N SigursB Kjellman
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C D PackH Zaghouani
Jan 25, 2002·The Journal of Infectious Diseases·Kathleen M NeuzilPeter F Wright
Nov 20, 2002·The Journal of Experimental Medicine·Fiona J CulleyPeter J M Openshaw
Oct 3, 1953·Nature·R E BILLINGHAMP B MEDAWAR
Nov 2, 2004·American Journal of Respiratory and Critical Care Medicine·Nele SigursBengt Kjellman
Jul 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Azzeddine DakhamaErwin W Gelfand
Dec 16, 2005·The New England Journal of Medicine·Niranjan BhatUNKNOWN Influenza Special Investigations Team
Jul 5, 2006·Viral Immunology·Dunja BruderRichard I Enelow
Oct 3, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Paula A VelillaClaire A Chougnet
Jul 3, 2007·Viral Immunology·Maryna C Eichelberger
Jan 30, 2008·The Journal of Experimental Medicine·Arnaud DidierlaurentTracy Hussell

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Citations

Aug 18, 2010·Viral Immunology·Josep Bassaganya-RieraRaquel Hontecillas
Nov 3, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Anders AnderssonAnders Lindén
Apr 12, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Famke AeffnerIan C Davis
Dec 6, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yashodhar P BhandarySreerama Shetty
Jan 3, 2013·Journal of Biochemical and Molecular Toxicology·Jordy SaraviaStephania A Cormier
May 27, 2016·Journal of Virology·Sergio M Quiñones-ParraKatherine Kedzierska
Jul 2, 2020·American Journal of Respiratory Cell and Molecular Biology·Andrew D PriggeKaren M Ridge
Sep 30, 2020·Vaccines·Kali F Crofts, Martha A Alexander-Miller
Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Khaled KhoufacheBéatrice Riteau
Jul 27, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·J Louise LinesBeth A Garvy
Nov 24, 2012·Parasite Immunology·V McDonaldF Petry
May 28, 2011·Journal of Perinatology : Official Journal of the California Perinatal Association·J MarticB Jankovic
Mar 1, 2012·Journal of Leukocyte Biology·Christine M Oshansky, Paul G Thomas
Oct 27, 2015·Viral Immunology·Samantha OliphantBeth A Garvy
Feb 14, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alison J CareyPeter D Katsikis
Sep 13, 2017·Seminars in Immunopathology·Kyra D ZensDonna L Farber
Dec 20, 2014·Annals of the American Thoracic Society·Philip M HansbroJay C Horvat
Sep 24, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael J RippleStephania A Cormier
Sep 1, 2017·The Journal of Experimental Medicine·Kyra D ZensDonna L Farber
Jun 20, 2018·Frontiers in Immunology·Katherine H RestoriElizabeth D Fixman
Nov 25, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Felix NauCharles D Nichols
Mar 9, 2012·Expert Review of Anti-infective Therapy·Eliana Akemi FutataMaria Notomi Sato
Sep 4, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Beth C Holbrook, Martha A Alexander-Miller
Feb 9, 2021·Frontiers in Immunology·Soumyaroop BhattacharyaThomas J Mariani
Apr 17, 2021·ACS Pharmacology & Translational Science·Thomas W FlanaganCharles D Nichols
Nov 26, 2015·Clinics in Perinatology·Gloria S Pryhuber
Mar 11, 2011·Particle and Fibre Toxicology·Shrilatha BalakrishnaStephania A Cormier
Dec 13, 2016·Pediatrics·Shairbanu ZinnaDon Sharkey

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