Incidence and antibiotic prescribing for clinically diagnosed urinary tract infection in older adults in UK primary care, 2004-2014

PloS One
Haroon AhmedChristopher Butler

Abstract

Urinary tract infections (UTI) are an important cause of morbidity and antibiotic use in older adults but there are little data describing disease burden in primary care. The aim of this study was to estimate the incidence of clinically diagnosed UTI and examine associated empirical antibiotic prescribing. We conducted a retrospective observational study using linked health records from almost one million patients aged ≥65 years old, registered with 393 primary care practices in England. We estimated incidence of clinically diagnosed UTI between March 2004 and April 2014, and used multilevel logistic regression to examine trends in empiric antibiotic prescribing. Of 931,945 older adults, 196,358 (21%) had at least one clinically diagnosed UTI over the study period. In men, the incidence of clinically diagnosed UTI per 100 person-years at risk increased from 2.81 to 3.05 in those aged 65-74, 5.90 to 6.13 in those aged 75-84, and 8.08 to 10.54 in those aged 85+. In women, incidence increased from 9.03 to 10.96 in those aged 65-74, 11.35 to 14.34 in those aged 75-84, and 14.65 to 19.80 in those aged 85+. Prescribing of broad-spectrum antibiotics decreased over the study period. There were increases in the proportion of older men (...Continue Reading

References

Dec 1, 1983·Journal of Epidemiology and Community Health·J E Anderson
Mar 10, 2001·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·M LoebL Strausbaugh
Nov 5, 2004·Australian Health Review : a Publication of the Australian Hospital Association·Lionel L Wilson
Aug 13, 2005·Pharmacy World & Science : PWS·Anna K SchweizerCiaran O'Neill
Jul 23, 2008·The Cochrane Database of Systematic Reviews·Monika Lutters, Nicole B Vogt-Ferrier
Jun 6, 2009·Journal of the American Geriatrics Society·Manisha Juthani-MehtaMary Tinetti
Mar 23, 2012·The Journal of Antimicrobial Chemotherapy·Pamela McCleanCarmel Hughes
Jun 13, 2012·Informatics in Primary Care·Tim Benson
Dec 6, 2012·JAMA Internal Medicine·Dimitri M DrekonjaJames R Johnson
Oct 10, 2013·Scandinavian Journal of Primary Health Care·Josephine McQuiston HaslundLars Bjerrum
Jun 8, 2015·International Journal of Epidemiology·Emily HerrettLiam Smeeth
Oct 7, 2015·PLoS Medicine·Eric I BenchimolUNKNOWN RECORD Working Committee
Jan 19, 2016·Journal of Clinical Epidemiology·Elizabeth R C MillettSara L Thomas
May 10, 2017·Open Forum Infectious Diseases·Jacob E SimmeringPhilip M Polgreen

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Citations

Jul 3, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Veronika TchesnokovaEvgeni V Sokurenko
Mar 29, 2019·Journal of the American Association of Nurse Practitioners·Sami M AloushBaha'a Al Bzoor
Sep 19, 2019·The Journal of Clinical Endocrinology and Metabolism·Alberto S TresoldiKrishnarajah Nirantharakumar
Aug 23, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Katia J BruxvoortSara Y Tartof
Jul 6, 2019·Nature Medicine·Xavier Didelot, Koen B Pouwels
Mar 17, 2020·Infectious Diseases·Marius A H SkowSigurd Høye
Sep 22, 2018·The Journal of Antimicrobial Chemotherapy·Helen J CurtisBen Goldacre
Dec 29, 2020·International Journal of Clinical Practice·Ibifuro I DokuboVincent J Gnanapragasam
Dec 20, 2020·International Journal of Environmental Research and Public Health·Ana López-de-AndrésRodrigo Jiménez-García
Apr 29, 2021·International Journal of General Medicine·Sheng YuanRuhai Bai
Jun 3, 2021·Journal of Clinical Medicine·Domingo Palacios-CeñaMarta Lopez-Herranz
Sep 30, 2021·PloS One·Jesús Redondo-SánchezÁngel Gil-de Miguel
Nov 24, 2021·JAMA : the Journal of the American Medical Association·Haroon AhmedEmma Thomas-Jones

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Methods Mentioned

BETA
urine sampling

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