Incidence and Clinical Predictors of Nonresponse to Hepatitis B Vaccination among Patients Receiving Hemodialysis: Importance of Obesity

Southern Medical Journal
Nimish PatelDarius L Mason

Abstract

The objectives of this study were to quantify the incidence of hepatitis B virus (HBV) vaccine nonresponse and identify clinical characteristics associated with vaccine nonresponse. A retrospective cohort study was conducted among patients undergoing hemodialysis (HD) receiving the HBV vaccine. Study inclusion criteria were age 18 years and older, receipt of HD treatment for ≥ 1 month, receipt of ≥ 1 dose of HBV vaccine, availability of anti-HB surface antibody (anti-HBs) laboratory values ≥ 2 weeks after last HBV vaccine, and prevaccine anti-HBs value <10 mIU/mL. Clinical data were abstracted from patients' medical records. The outcome of interest was vaccine nonresponse, defined as anti-HBs values <10 IU/mL. Multivariate regression was used to determine variables independently associated with vaccine nonresponse. Kaplan-Meier estimates were constructed for determining HBV vaccine response retention. Of the 119 patients evaluated, nonresponse was observed in 58%. Mean age at first vaccination for vaccine responders and nonresponders was 58.8 ± 16.5 and 65.9 ± 14.1 (P = 0.01), respectively. Variables independently associated with nonresponse were age 58 years and older (adjusted relative risk, 95% confidence interval 1.62, 1.06...Continue Reading

Citations

May 12, 2016·Expert Review of Vaccines·Alicja E GrzegorzewskaWojciech Warchoł
May 10, 2018·Seminars in Dialysis·Georges KosmadakisDidier Aguilera
Nov 9, 2019·Journal of Nephrology·Suwasin UdomkarnjananunPaweena Susantitaphong
Jan 12, 2021·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Fabrizio FabriziEzequiel Ridruejo
Jun 26, 2021·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Fabrizio FabriziEzequiel Ridruejo

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