PMID: 10099925Apr 1, 1999Paper

Incidence and clinical relevance of coronary calcification detected by electron beam computed tomography in heart transplant recipients

European Heart Journal
P F LudmanM H Yacoub

Abstract

Patients treated by cardiac transplantation who survive beyond one year are at significant risk from fatal coronary artery disease. The development of coronary artery calcification in these patients is discussed and methods available to detect it are reviewed. To assess the clinical importance of coronary artery calcium in heart transplant recipients. In a cohort of 102 cardiac transplant recipients, electron beam computed tomography was used to measure calcium in the coronary arterial wall 63 days to 9.1 years (median 4.6 years) after transplantation. The results were compared with angiographic findings and with conventional coronary disease risk factors. The patients were followed for a mean of 2.12 years (1.2-4.02 years) to assess the relationship between these findings and future cardiac events. Forty-one (40.2%) had a stenosis of > 24% in one or more major coronary artery at angiography. Forty-six (45%) had a coronary calcium score > 0. The absence of calcium had a negative predictive value with respect to angiographic disease in any vessels of 87.5%. Logistic regression revealed that dyslipidaemia, systemic hypertension and organ ischaemic time were significant predictors of calcification. At follow-up, both an abnormal c...Continue Reading

Citations

Mar 3, 2006·Current Atherosclerosis Reports·Amandeep Dhaliwal, Vinay Thohan
Mar 14, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Ani C AnyanwuM H Yacoub
Dec 16, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Michael DandelR Hetzer
Mar 18, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Philipp PichlerDietmar Glogar
Dec 25, 2004·Seminars in Thoracic and Cardiovascular Surgery·Christopher HerzogThomas J Vogl
Jul 13, 2004·The American Journal of Cardiology·Norman B RatliffMark R Pritzker
Jul 7, 2005·The Journal of Thoracic and Cardiovascular Surgery·Giovanni MelinaGuang-Zhong Yang
Jul 12, 2005·Biochemical and Biophysical Research Communications·Agneta SimionescuNarendra Vyavahare

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