Incidence and determinants of myocardial infarction following percutaneous coronary interventions according to the revised Joint Task Force definition of troponin T elevation

International Journal of Cardiology
Richard F AlcockSaul Benedict Freedman

Abstract

Elevations in troponin T (TnT) occur frequently following percutaneous coronary intervention (PCI) and are associated with an adverse prognosis. The Joint ESC/ACC/AHA/WHF Task Force have released a proposal for a universal definition of myocardial infarction (MI), including diagnostic criteria for PCI associated MI. This is based on a TnT cut-point of more than three times the 99th percentile (0.03 ng/ml), which better reflects the precision of the assay. Our study investigated the incidence and predictive factors of a PCI associated MI, using the revised definition. 325 patients were studied following PCI with stenting. TnT was collected at both 8 and 18 h following PCI in patients with either stable or unstable angina and normal baseline TnT levels. Comparison was made of both clinical and procedural characteristics of patients with and without a rise in TnT following intervention, using cut points of 0.01 and 0.03 ng/ml. TnT was elevated > or = 0.03 ng/ml in 27% and > or = 0.01 ng/ml in 39% of patients following PCI. Troponin elevation was significantly more likely in those patients who experienced peri-procedural ischemic symptoms or EKG changes, or in whom abciximab was used. The variables associated with a troponin rise s...Continue Reading

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Feb 4, 2011·The New England Journal of Medicine·Abhiram Prasad, Joerg Herrmann
Jun 10, 2011·Critical Care : the Official Journal of the Critical Care Forum·Ritesh Maharaj, Victoria Metaxa
Dec 25, 2015·Journal of the American College of Cardiology·Gerry P McCannAnthony H Gershlick
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Aug 26, 2011·International Journal of Cardiology·Austin Chin Chwan NgLeonard Kritharides

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