Incidence and geographical distribution of sudden infant death syndrome in relation to content of nitrate in drinking water and groundwater levels

European Journal of Clinical Investigation
M GeorgeL Holmberg

Abstract

Previous studies indicate that the enteral bacterial urease is inhibited in victims of sudden infant death syndrome (SIDS). One possible inhibitor of this bacterial activity is nitrate. If ambient pollution by nitrate is involved in the etiology of SIDS only a fraction of the nitrate concentration not infrequently found in drinking water would be enough for this inhibition. Occurrence of SIDS (n = 636) in Sweden during the period 1990 through 1996 were analysed regarding geographical and seasonal distribution in relation to the nitrate concentration in drinking water and changes in the groundwater level. Both the birth rate and the incidence of SIDS decreased during the study period. One quarter of the municipalities constituting 11% of the population had no cases, the maximum incidence being 6.5 per 1000 live births. Seasonality: The northernmost parts of the country had its highest incidence when the rest of the country had its lowest incidence, and the occurrence of individual deaths was associated with the recharge of groundwater which increases its nitrate content. The local incidence of SIDS was correlated (rs = 0.34-0.87) to maximally recorded concentrations of nitrate in drinking water. The seasonal distribution of SIDS...Continue Reading

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Citations

Jan 16, 2007·Analytical and Bioanalytical Chemistry·Giaan A Alvarez-RomeroMaría Teresa Ramírez-Silva
Nov 26, 2016·Environmental Science and Pollution Research International·Yuanzheng ZhaiXiaodong Pan
Sep 6, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Christina VlachouJürgen König
Dec 13, 2016·Pediatrics·Rachel Y Moon, UNKNOWN TASK FORCE ON SUDDEN INFANT DEATH SYNDROME

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