Incidence and influence of GB virus C and hepatitis C virus infection in patients undergoing bone marrow transplantation

Bone Marrow Transplantation
H AkiyamaM Mayumi

Abstract

Markers of GB virus C (GBV-C) and hepatitis C virus (HCV) were sought in 80 patients before and after they underwent BMT in a metropolitan hospital in Tokyo between 1990 and 1996. RNA of GBV-C was detected in 14 (18%) patients before BMT. Of the 55 patients who had been transfused, 14 (25%) possessed GBV-C RNA at a frequency significantly higher than in the 25 untransfused patients who were all negative (P < 0.01). HCV RNA was detected in three of the 55 (5%) transfused patients, but in none of the 25 untransfused patients. Sera at 3 months after BMT were available for 57 patients. GBV-C RNA persisted in all 10 patients who were infected before BMT, while it was detected in five of the remaining 47 (11%) patients who were not. However, persistent and/or ongoing GBV-C infection had no appreciable influence on patient morbidity or mortality. Two of the 57 patients were positive for HCV RNA before BMT and this persisted after BMT in both. HCV RNA became positive in eight of the remaining 55 (15%) patients who were negative before BMT. Of the 14 patients who received transfusions screened by the first-generation test at BMT, seven (50%) became positive for HCV RNA, a rate significantly higher than the one of 41 (2%) patients who re...Continue Reading

Citations

May 1, 2007·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Ren ZhangYun-Shao He
May 27, 2021·Reviews in Medical Virology·Joseph Zimmerman, Jason T Blackard
Aug 21, 2021·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Marianne GraningerElisabeth Puchhammer-Stöckl

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