Incidence and location of positive nonsentinel lymph nodes in head and neck melanoma

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
D E GyorkiSnehal G Patel

Abstract

The complex lymphatic drainage in the head and neck makes sentinel lymph node biopsy (SLNB) for melanomas in this region challenging. This study describes the incidence, and location of additional positive nonsentinel lymph nodes (NSLN) in patients with cutaneous head and neck melanoma following a positive SLNB. A retrospective review was performed using a single institution prospective database. Patients with a primary melanoma in the head or neck with a positive cervical SLNB were identified. The lymphadenectomy specimen was divided intraoperatively into lymph node levels I-V, and NSLN status determined for each level. Of 387 patients with melanoma of the head and neck who underwent cervical SLNB, 54 had a positive SLN identified (14%). Thirty six patients (67%) underwent immediate completion lymph node dissection (CLND) of whom eight patients (22%) had a positive NSLN. The remaining 18 patients (33%) did not undergo CLND and were observed. Half of positive NSLNs (50%) were in the same lymph node level as the SLN and 33% were in an immediately adjacent level; only two patients were found to have NSLNs in non-adjacent levels. The only factor predictive of NSLN involvement was the size of the tumor deposit in the SLN>0.2 mm (p ...Continue Reading

References

Mar 18, 2000·Archives of Otolaryngology--head & Neck Surgery·J D WagnerJ T Hayes
Mar 12, 2002·Archives of Otolaryngology--head & Neck Surgery·Snehal G PatelDennis H Kraus
Jun 28, 2005·Journal of the American College of Surgeons·Michael S SabelTimothy M Johnson
Sep 2, 2005·Annals of Surgery·Donald L MortonUNKNOWN Multicenter Selective Lymphadenectomy Trial Group
Sep 29, 2006·The New England Journal of Medicine·Donald L MortonUNKNOWN MSLT Group
Jul 9, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey E GershenwaldMerrick I Ross
Nov 4, 2008·Annals of Surgical Oncology·Charlotte AriyanDaniel Coit
Nov 20, 2009·Annals of Surgical Oncology·T Peter KinghamDaniel G Coit
May 19, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Emanuela RomanoPaul B Chapman
Sep 9, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rajmohan MuraliRichard A Scolyer
Apr 27, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Augustinus P T van der PloegAlexander M M Eggermont
May 5, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Nicole de RosaWalter T Lee
Jan 13, 2012·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Valerie A SmithEric J Lentsch
Apr 27, 2012·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Brian M ParrettStanley P L Leong

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Citations

Sep 24, 2014·The Surgical Clinics of North America·Jerry CheriyanAndrew Urquhart
Sep 25, 2015·The British Journal of Dermatology·J MoserF Trautinger
Jul 17, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S PasqualiC R Rossi
Feb 12, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·John E HanksScott A McLean
Mar 20, 2018·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·D EvrardA Moya-Plana
Mar 1, 2017·Melanoma Management·Madalyn G NeuwirthGiorgos C Karakousis
Jan 20, 2021·Head & Neck·Ryan P GoepfertJeffrey E Gershenwald

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