Incidence and Mortality Risk Spectrum Across Aggressive Variants of Papillary Thyroid Carcinoma.

JAMA Oncology
Allen S HoZachary S Zumsteg

Abstract

While well-differentiated papillary thyroid carcinoma (WDPTC) outcomes have been well characterized, the prognostic implications of more aggressive variants are far less defined. The rarity of these subtypes has led to their consolidation as intermediate risk for what are in fact likely heterogeneous diseases. To analyze incidence, clinicopathologic characteristics, and outcomes for aggressive variants of papillary thyroid carcinoma (PTC). This cohort study used data from 2000 to 2016 from hospital-based and population-based US cancer registries to analyze aggressive PTC variants, including diffuse sclerosing (DSV), tall-cell (TCV), insular, and poorly differentiated (PDTC) subtypes. These variants were compared against WDPTC and anaplastic cases. Data analysis was conducted from January 2019 to October 2019. Age-adjusted incidence was calculated via annual percentage change (APC) using the weighted least-squares method. Overall survival and disease-specific survival were analyzed via Cox regression. Propensity-score matching was used to adjust survival analyses for clinical and demographic covariates. Collectively, 5447 aggressive PTC variants were identified (including 415 DSV, 3339 TCV, 362 insular, and 1331 PDTC cases), as ...Continue Reading

References

Jan 29, 2000·Statistics in Medicine·H J KimD N Midthune
Mar 30, 2004·Journal of Surgical Oncology·Mark SywakTravis Ogilvie
Nov 14, 2006·Human Pathology·Jean Jacques MichelsStephane Bardet
Jan 31, 2007·Statistical Methods in Medical Research·Ram C TiwariZhaohui Zou
Aug 19, 2007·Thyroid : Official Journal of the American Thyroid Association·Ronald A GhosseinR Michael Tuttle
Feb 16, 2010·Thyroid : Official Journal of the American Thyroid Association·Luc G T MorrisIan Ganly
Sep 9, 2010·Head & Neck·Carl E SilverAlfio Ferlito
Feb 12, 2011·Thyroid : Official Journal of the American Thyroid Association·Concetto RegalbutoVincenzo Pezzino
Apr 23, 2013·Thyroid : Official Journal of the American Thyroid Association·Eric J KuoSanziana A Roman
Nov 23, 2013·Thyroid : Official Journal of the American Thyroid Association·Ian GanlyRonald Ghossein
Feb 22, 2014·JAMA Otolaryngology-- Head & Neck Surgery·Louise Davies, H Gilbert Welch
Jul 16, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mingzhao XingJustin Bishop
Nov 25, 2014·Cell·UNKNOWN Cancer Genome Atlas Research Network
Feb 16, 2016·The Journal of Clinical Investigation·Iñigo LandaJames A Fagin
Mar 30, 2016·The Journal of Clinical Endocrinology and Metabolism·Denise P MomessoR Michael Tuttle
Jun 29, 2016·Thyroid : Official Journal of the American Thyroid Association·Pasqualino MalandrinoRiccardo Vigneri
Feb 28, 2017·JAMA Oncology·Daniel J BoffaDavid P Winchester
May 12, 2017·JAMA Otolaryngology-- Head & Neck Surgery·Louise Davies, Luc G T Morris
May 12, 2017·JAMA : the Journal of the American Medical Association·UNKNOWN US Preventive Services Task ForceChien-Wen Tseng
Sep 1, 2017·JAMA Otolaryngology-- Head & Neck Surgery·R Michael TuttleLuc G T Morris
Nov 2, 2017·Thyroid : Official Journal of the American Thyroid Association·Edmund S Cibas, Syed Z Ali
Jan 10, 2018·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Feb 2, 2018·Journal of Clinical Medicine·Benjamin E AnsaSelina A Smith
Apr 5, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nikita PozdeyevDaniel W Bowles
Jul 28, 2018·Translational Lung Cancer Research·Patricia M de GrootReginald F Munden
Aug 22, 2018·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Tyler A JanzEric J Lentsch
Aug 29, 2018·Current Opinion in Endocrinology, Diabetes, and Obesity·Allen S HoWendy L Sacks
Dec 14, 2018·Journal of the National Comprehensive Cancer Network : JNCCN·Robert I HaddadLisa A Gurski
Mar 16, 2019·The Journal of Clinical Endocrinology and Metabolism·R Michael Tuttle, Ali S Alzahrani
May 18, 2019·World Journal of Surgery·Junko AkaishiKoichi Ito
Aug 14, 2019·Thyroid : Official Journal of the American Thyroid Association·Allen S HoZachary S Zumsteg
Oct 22, 2019·Current Opinion in Oncology·Evan WalgamaAllen S Ho

❮ Previous
Next ❯

Citations

Apr 10, 2020·JAMA Oncology
Jul 24, 2020·Current Opinion in Endocrinology, Diabetes, and Obesity·Sara Cartwright, Abbey Fingeret
Aug 19, 2020·Annals of Surgical Oncology·Allen S HoZachary S Zumsteg
Sep 29, 2020·The Journal of Clinical Endocrinology and Metabolism·Cari M KitaharaMeredith S Shiels
Mar 5, 2021·The Lancet. Diabetes & Endocrinology·Adalberto Miranda-FilhoLuigino Dal Maso
Jun 26, 2021·Clinical Endocrinology·Sabbir T RahmanSusan J Jordan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.