Incidence and outcome of fungal infections in pediatric small bowel transplant recipients

Transplant Infectious Disease : an Official Journal of the Transplantation Society
Diana F FlorescuAndre C Kalil

Abstract

Data on the incidence, timing, and outcome of fungal infections in pediatric small bowel transplantation (SBT) are lacking. Cases of pediatric SBT from January 2003 through December 2007 were collected. Standard induction was with thymoglobulin and/or basiliximab and maintenance immunosuppression was a tacrolimus-based regimen. Chi-square was used for categorical variables and Kaplan-Meier for survival analyses. A total 98 recipients were included; 25 patients developed 59 episodes of Candida infections and 4 episodes of invasive aspergillosis (incidence 25.5%, 95% confidence interval [CI] 17%, 34%). Of the Candida species, 37.3% were Candida albicans and 62.7% non-albicans Candida. Of all yeast infections, 66.1% were fungemia, 28.8% intra-abdominal infections, 1.7% empyema, and 3.4% urinary tract infection. Of the Candida intra-abdominal infections, 41.2% developed in the first month post transplantation, while 79.5% of candidemia developed after >6 months. Median time from transplantation to fungal infection was significantly shorter for abdominal infections compared with fungemia (9 versus 163 days; P=0.004). All-cause mortality was not significantly different between patients with and without fungal infections (32.3% versus...Continue Reading

References

Sep 15, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·N Singh
Jun 8, 2001·Transplantation·L CicaleseJ Reyes
Jun 29, 2001·Transplant Infectious Disease : an Official Journal of the Transplantation Society·J E Patterson
Dec 4, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S AsciogluUNKNOWN Mycoses Study Group of the National Institute of Allergy and Infectious Diseases
Apr 14, 2007·Current Drug Targets·A C KalilA G Freifeld
Dec 21, 2007·The New England Journal of Medicine·Jay A Fishman
May 16, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David L HornKaren M Webster
Sep 4, 2009·The New England Journal of Medicine·Thomas M Fishbein
Sep 29, 2009·Seminars in Pediatric Surgery·Alastair J W MillarKhalid Sharif
Dec 17, 2009·The New England Journal of Medicine·Loris PironiAndré Van Gossum

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Citations

Nov 19, 2011·The Pediatric Infectious Disease Journal·Diana F FlorescuAndre C Kalil
May 10, 2012·Future Microbiology·Shmuel Shoham, Kieren A Marr
May 30, 2013·Infectious Disease Clinics of North America·Joseph G TimponeThomas M Fishbein
Mar 20, 2015·Current Gastroenterology Reports·Askin Erdogan, Satish S C Rao
May 17, 2018·Expert Review of Clinical Immunology·Paul J Deziel, Raymund Razonable
Jul 22, 2015·Infection and Immunity·Jessica C HargartenAudrey L Atkin
May 11, 2018·The Pediatric Infectious Disease Journal·Jared W ClouseRichard S Mangus
Mar 13, 2019·Clinical Transplantation·Diana F FlorescuUNKNOWN AST Infectious Diseases Community of Practice
Dec 18, 2015·Einstein·Ionut NegoiMircea Beuran
May 7, 2015·Current Opinion in Organ Transplantation·Diana F Florescu, Uriel Sandkovsky
Nov 22, 2013·Current Opinion in Gastroenterology·Lara Danziger-Isakov
May 19, 2019·Clinical Transplantation·Ghady HaidarUNKNOWN American Society of Transplantation Infectious Diseases Community of Practice

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