Incidence and outcomes of cancer treatment-related cardiomyopathy among referrals for advanced heart failure

Cardio-Oncology
Raquel Araujo-GutierrezBarry H Trachtenberg

Abstract

Approximately 2-3% of patients undergoing advanced heart failure therapies such as left ventricular assist devices (LVAD) and orthotropic heart transplantation (OHT) have chemotherapy-related cardiomyopathy, according to analyses of large databases such as United Network for Organ Sharing (UNOS) or Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) registries. While these studies have shown similar survival outcomes post-interventions, these databases by definition exclude patients referred for advanced therapies but do not receive them, and thus there is little data on overall outcomes of such patients. Given the lack of nuance in the diagnoses in large registries and the possibility that many cancer treatment-related cardiomyopathy (CCMP) patients might be misclassified by the generic "non-ischemic" or "dilated" cardiomyopathies, we investigated the incidence and clinical outcomes of CCMP patients among advanced heart failure (HF) referrals at a single high volume institution. All referrals from 2013 to 2016 were evaluated for type of cardiomyopathy, with careful chart review. Outcomes such as LVAD, OHT and death were compared between CCMP and other cardiomyopathies. Of 553 referrals for advanced H...Continue Reading

References

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Citations

Aug 10, 2020·Current Cardiology Reports·Domenico D'AmarioGianluigi Savarese
Sep 21, 2021·Frontiers in Cardiovascular Medicine·Andrea MontisciClaudio Napoli

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