Incidence and outcomes of extremity soft-tissue sarcomas in children

The Journal of Surgical Research
Michael C CheungJuan E Sola

Abstract

We studied the outcomes of pediatric extremity tumors on a population scale. The Surveillance, Epidemiology, and End Results database (1973-2006) was queried for all patients under 20 y of age. Overall, 1175 patients were identified. The median age at diagnosis was 12 y, but most patients were ≥10 y of age (72%, n = 842). Most tumors were non-rhabdomyosarcoma soft tissue sarcomas (NRSTS) (79%, n = 879). The most common tissue of origin was muscle (43%, n = 474). Most rhabdomyosarcoma (RMS) (n = 220) were alveolar type (n = 140). Most patients presented with local disease (64%, n = 699), and underwent surgical intervention (88%, n = 1027), but did not have radiotherapy (62%, n = 710). RMS was more likely to present in younger children (P < 0.001) and with distant disease (P < 0.001). Older patients were more likely to receive radiotherapy than infants (P < 0.001). Overall 5-y survival was 79%. RMS had significantly worse 5-y survival (56% versus 85% for NRSTS, P < 0.001). Surgical intervention was associated with higher 5-y survival (84% versus 48%, P < 0.001). Radiotherapy was associated with worse 5-y survival (74% versus 83%, P = 0.002). Multivariate analysis identified RMS (HR 2.20, P < 0.001), nerve and muscle (not synovial...Continue Reading

References

Feb 1, 1990·Journal of Pediatric Surgery·M P LaQuagliaP R Exelby
Nov 1, 1993·Seminars in Surgical Oncology·M P LaQuaglia
Feb 25, 2003·Cancer·Lihua LiuUNKNOWN Surveillance, Epidemiology and End Results Childhood Cancer Linkage Group
Nov 5, 2003·Medical and Pediatric Oncology·Bhaskar N Rao, Carlos Rodriguez-Galindo
Feb 18, 2004·Pediatric Blood & Cancer·Harish S Hosalkar, John P Dormans
Mar 16, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrea FerrariFranca Fossati-Bellani
May 10, 2005·Expert Review of Anticancer Therapy·Andrea Ferrari, Michela Casanova
Nov 6, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Andrea FerrariLuigi Mariani
May 24, 2008·The Journal of Surgical Research·Juan C GutierrezJuan E Sola
Sep 1, 2007·Journal of Children's Orthopaedics·Michela CasanovaAndrea Ferrari
Jun 30, 2009·The Journal of Surgical Research·Ying ZhugeJuan E Sola
Jul 28, 2009·The Journal of Surgical Research·Anthony R HoganJuan E Sola

❮ Previous
Next ❯

Citations

Sep 20, 2012·Sarcoma·Eric J StanelleMichael P La Quaglia
Jan 21, 2014·Journal of Pediatric Surgery·Bassan J AllanJuan E Sola
Apr 23, 2013·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Bassan J AllanJuan E Sola
Apr 11, 2013·The Journal of Surgical Research·Bassan J AllanJuan E Sola
Jan 18, 2012·Seminars in Pediatric Surgery·Andrea Hayes-Jordan
Feb 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Min Rex CheungVincent Yeung
Feb 4, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Rex Cheung
Jun 28, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Min Rex Cheung

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Surgical Research
Eduardo A PerezJuan E Sola
The Journal of Surgical Research
Holly L NevilleJuan E Sola
The Journal of Surgical Research
Anthony R HoganJuan E Sola
© 2021 Meta ULC. All rights reserved