Incidence and predictive factors of transaminase elevation in patients consulting for dengue fever in Cayenne Hospital, French Guiana

Transactions of the Royal Society of Tropical Medicine and Hygiene
Félix DjossouMathieu Nacher

Abstract

The objective of the study was to determine the incidence of transaminase elevation during dengue, and its predictive factors. In 2013, a longitudinal study was performed using data from all cases of dengue seen in Cayenne Hospital. Cox proportional modeling was used. Signs of major transaminase elevation were defined as an increase in aspartate amino transferase (AST) or alanine amino transferase (ALT) concentration over 10 times the normal value (10N). There were 1574 patients and 13 249 person-days of follow-up. The incidence rate for signs of transaminase elevation (10N) was 0.55 per 100 person-days. Six patients had major transaminase elevation with AST>1000 units (0.43 per 1000 patient-days), and 73 patients (4.6%) developed transaminase elevation with AST >10N. The variables independently associated with major transaminase elevation were hyponatremia, low platelets, dehydration, hematocrit increase, food intolerance, positive nonstructural protein 1 (NS1), age over 15 years and the notion of paracetamol intake. Although very frequent, the incidence of major transaminase elevation was lower than reported elsewhere perhaps because of good access to care, or of the particular serotype causing this epidemic. The patients wit...Continue Reading

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Jan 7, 2017·The Pediatric Infectious Disease Journal·Narcisse ElengaJulie Dufour
Sep 7, 2017·Revista Do Instituto De Medicina Tropical De São Paulo·Luciana de Almeida Silva TeixeiraGabriel Antonio Nogueira Nascentes
Jan 24, 2020·Expert Review of Anti-infective Therapy·Po Ying ChiaYee Sin Leo

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