Incidence and Predictors for Cardiovascular Disease in Chinese Patients With Type 2 Diabetes Mellitus - A Population-Based Retrospective Cohort Study

Journal of Diabetes and Its Complications
Eric Yuk Fai WanCindy Lo Kuen Lam

Abstract

This study aimed to estimate the 5-year incidence rate of cardiovascular disease (CVD) and determine predictive factors of new CVD in Chinese patients with type 2 diabetes mellitus (T2DM). A retrospective cohort study was conducted on 115,470 T2DM patients aged ≥18years without any history of CVD. Cox Proportional Hazard regression stratified by gender was performed to explore predictive factors of CVD. For 5.3years median follow-up, the overall incidence rate of CVD per 1,000 person-years was 17.2 (95% CI: 16.9-17.6), without significant gender difference. Predictors of higher risk of CVD were older age, current smoking, longer duration of T2DM, more severe stage of chronic kidney disease, anti-hypertensive and oral anti-diabetic drugs needed, and higher body mass index (BMI), systolic and diastolic blood pressure (SBP and DBP), total cholesterol/high-density lipoprotein-cholesterol ratio (TC/HDL-C ratio) and urine albumin/creatinine ratio (ACR). Lipid-lowering agents needed in men, and ex-smoking and higher hemoglobin A1c (HbA1c) in female were the additional predictive factors of increased CVD risk. Smoking, BMI, HbA1c, SBP, DBP, TC/HDL-C ratio and ACR were found to be modifiable risk factors of new CVD in Chinese T2DM patie...Continue Reading

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Citations

Aug 23, 2018·Journal of Comparative Effectiveness Research·Bin WuHaixiang Wu
Dec 29, 2020·Journal of Gastroenterology and Hepatology·Ho Soo ChunSeung Up Kim

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