Incidence and predictors of HBV relapse after cessation of nucleoside analogues in HBeAg-negative patients with HBsAg ≤ 200 IU/mL

Scientific Reports
Chih-Chien YaoChien-Hung Chen

Abstract

The predictors of hepatitis B virus (HBV) relapse and HBsAg loss after cessation of nucleos(t)ide analogues (NA) in HBeAg-negative patients with end-of-treatment HBsAg ≤ 200 IU/mL remains unclear. The study recruited 119 chronic hepatitis B (CHB) patients who achieved end-of-treatment HBsAg ≤ 200 IU/mL, were treated with lamivudine (n = 34) and entecavir (n = 85). The 5-year rates of post-treatment virological relapse, clinical relapse, and HBsAg loss at 60 months were 39.4%, 27.6%, and 45.9%, respectively. Cox regression analysis revealed that HBV DNA at entry and end-of-treatment HBsAg levels were independent predictors of virolgical and clinical relapse. HBV genotype C and end-of-treatment HBsAg were independent factors of HBsAg loss. Patients with a combination of end-of-treatment HBsAg < 50 IU/mL and HBV DNA < 2 × 105 IU/mL at entry experienced the lowest virological and clinical relapse rates (5% and 0% at 60 months, respectively). In contract, patients with a combination of end-of-treatment HBsAg ≥ 50 IU/mL and HBV DNA ≥ 2 × 105 IU/mL at entry experienced high virological and clinical relapse (80.7% and 71.5% at 60 months, respectively). No patients experienced hepatic decompensation when clinical relapse occurred after ...Continue Reading

References

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Citations

Nov 7, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Wen-Juei JengYun-Fan Liaw
May 11, 2019·Reviews in Medical Virology·Yongbin WuBao Zhang
Sep 4, 2019·Nature Reviews. Gastroenterology & Hepatology·Yun-Fan Liaw
Dec 19, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jiaye LiuAiqiang Xu
Feb 26, 2020·Cells·Margarita Papatheodoridi, George Papatheodoridis
Mar 13, 2020·Expert Review of Gastroenterology & Hepatology·Emilia Hadziyannis, Stephanos Hadziyannis
May 30, 2020·Nature Reviews. Gastroenterology & Hepatology·Peter A RevillMargaret Littlejohn
Apr 4, 2021·Journal of Gastroenterology and Hepatology·Aunchalee JaroenlapnopparatPisit Tangkijvanich
Aug 11, 2021·Viruses·Bingqian Qu, Richard J P Brown
Dec 12, 2021·Hepatology Communications·Hannah S J ChoiNorah A Terrault
Dec 11, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Margarita PapatheodoridiGeorge V Papatheodoridis

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Methods Mentioned

BETA
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