Incidence and predictors of low chemotherapy dose-intensity in aggressive non-Hodgkin's lymphoma: a nationwide study

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Gary H LymanRichard I Fisher

Abstract

To assess the incidence of and risk factors for reduced relative dose-intensity (RDI) in patients treated with chemotherapy for aggressive non-Hodgkin's lymphoma (NHL). A nationwide survey was conducted of 567 oncology practices with data extracted from the records of 4,522 patients with aggressive NHL treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP); CHOP-rituximab (CHOP-R); or cyclophosphamide, mitoxantrone, vincristine, and prednisone (CNOP). The primary outcome was the average RDI for each regimen based on both planned and reference standards. Other assessments included the incidence of febrile neutropenia and patterns of colony-stimulating factor (CSF) use, as well as the average RDI in high-risk subgroups. Dose reductions > or = 15% occurred in 40% of patients and treatment delays > or = 7 days occurred in 24% of patients, resulting in 53% and 48% of patients receiving an RDI less than 85% of the minimum six-cycle and National Comprehensive Cancer Network guideline standards, respectively. Reduced RDI was more prevalent in older patients, with 60% of patients older than 60 years receiving RDI less than 85%. Multivariate analysis identified several independent predictors for reduced RDI, inclu...Continue Reading

References

Mar 1, 1992·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S PavlovskyH Magnasco
Jun 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·L W KwakS J Horning
Mar 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D O DixonH E Wilson
Apr 1, 1984·Journal of the American Geriatrics Society·J O Armitage, J F Potter
Jan 1, 1994·Annals of Oncology : Official Journal of the European Society for Medical Oncology·V ZagonelS Monfardini
Dec 1, 1994·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M BertiniM Pini
Oct 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P SonneveldB Lowenberg
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·V Trillet-LenoirD Tomita
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN International Non-Hodgkin's Lymphoma Prognostic Factors Project
Jan 25, 2002·The New England Journal of Medicine·Bertrand CoiffierChristian Gisselbrecht
Jun 11, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A WunderlichUNKNOWN German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL)
Aug 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J K DoorduijnP Sonneveld
Dec 16, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gary H LymanJeffrey Crawford
Feb 21, 2004·CA: a Cancer Journal for Clinicians·Ahmedin JemalUNKNOWN American Cancer Society
Jul 1, 2003·Journal of the National Comprehensive Cancer Network : JNCCN·David C DaleGary H Lyman

❮ Previous
Next ❯

Citations

Mar 21, 2008·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Ruth PettengellUNKNOWN Impact of Neutropenia in Chemotherapy-European Study Group (INC-EU)
Feb 25, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Wylie HosmerMitchell Wong
May 18, 2006·Breast Cancer Research and Treatment·Michelle ShayneUNKNOWN ANC Study Group
Oct 6, 2011·Breast Cancer Research and Treatment·Yunwei HanXin Wang
Aug 31, 2013·Current Hematologic Malignancy Reports·Michael K Keng, Mikkael A Sekeres
Jul 17, 2013·Nature Reviews. Clinical Oncology·Gary H Lyman, Alex Sparreboom
Feb 24, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B J PaessensA Ihbe-Heffinger
Jun 15, 2011·Journal of the National Cancer Institute·Nicole M Kuderer, Gary H Lyman
Jun 5, 2007·Current Opinion in Oncology·Gary H Lyman, Michelle Shayne
Aug 20, 2009·Journal of Experimental & Clinical Cancer Research : CR·Yoshiki TeradaMasayuki Hino
Nov 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Xianglin L DuShenying Fang
Nov 28, 2012·Journal of Oncology Practice·Gary H Lyman
May 29, 2009·Annals of Surgical Oncology·Laura A LambertPaul F Mansfield
Jul 25, 2009·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·William RenwickMichael Green
Mar 10, 2010·Drugs & Aging·Paolo F CaimiHillard M Lazarus
Jun 2, 2011·Journal of Clinical and Experimental Hematopathology : JCEH·Hiroki YamaguchiKoiti Inokuchi
Feb 19, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Lee S SchwartzbergEsteban Abella
Apr 29, 2014·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Andrew WeaverLionel Tarassenko
Sep 6, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Rodrigo O PerezIvan Cecconello
Jan 12, 2011·Journal of Cancer Research and Clinical Oncology·Yujin KobayashiJin Takeuchi
Jul 28, 2013·Leukemia & Lymphoma·Mari YoshiharaShinya Kimura
Nov 1, 2007·Expert Opinion on Investigational Drugs·Alissa Huston, Gary H Lyman
Dec 2, 2004·Expert Opinion on Biological Therapy·Rami S Komrokji, Gary H Lyman
Jan 25, 2011·Expert Opinion on Pharmacotherapy·Emmanouil SaloustrosVassilis Georgoulias
Jan 23, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Linda S EltingSharon H Giordano
Feb 23, 2008·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·Nora Kearney, Christopher Friese

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Gary H LymanJeffrey Crawford
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Thomas J SmithAntonio C Wolff
Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Ruth PettengellImpact of Neutropenia in Chemotherapy-European Study Group (INC-EU)
© 2021 Meta ULC. All rights reserved