Incidence and prevalence of amyotrophic lateral sclerosis in urban China: a national population-based study

Journal of Neurology, Neurosurgery, and Psychiatry
Lu XuDongsheng Fan

Abstract

Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease and information on disease burden of ALS in mainland China was limited. We aimed to estimate the prevalence and incidence of ALS in China. We used 2012-2016 data from China's Urban Employee Basic Medical Insurance and Urban Residence Basic Medical Insurance, covering approximately 0.43 billion individuals. ALS cases were identified by the primary diagnosis (International Classification of Diseases code or text of diagnosis) in the insurance database. The crude prevalence and incidence in 2016 were 2.91 per 100 000 person-years (95% CI 2.31 to 3.58) and 1.65 (95% CI 1.33 to 2.01), respectively. The standardised prevalence and incidence based on 2010 Chinese census data were 2.97 (95% CI 2.91 to 3.03) and 1.62 (95% CI 1.58 to 1.67), respectively. The annual prevalence between 2013 and 2016 remained relatively constant, ranging from 2.91 (95% CI 2.31 to 3.58) in 2016 to 3.29 (95% CI 2.51 to 4.17) in 2014 (linear regression: β=-0.129, p=0.104). Both rates peaked in the group aged 75-79 years. The prevalence and incidence of ALS in mainland China were lower than those in developed countries, and maintained a relatively stable trend. The age at onset and age at...Continue Reading

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Citations

Oct 22, 2020·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Nur Adilah Abdul AzizNortina Shahrizaila
Nov 22, 2020·Molecular Neurobiology·Yong-Ping ChenHui-Fang Shang
Jan 30, 2021·Scientific Reports·Lu XuPei Gao
Feb 5, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Lu XuDongsheng Fan
May 29, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Lu ChenDongsheng Fan
Jul 19, 2021·Journal of Neurology·Ji HeDongsheng Fan
Jul 20, 2021·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Di HeLiying Cui
Sep 22, 2021·Journal of Medical Genetics·Yong-Ping ChenHui-Fang Shang

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