Incidence and prevalence of congenital anomalies in low- and middle-income countries: A systematic review

Journal of Pediatric Surgery
Asra ToobaieDan Poenaru

Abstract

In the absence of robust data from low- and middle-income countries (LMICs), most disease burden estimates and related resource allocation choices are based on historic Northern demographics. We hypothesize that significant discrepancies exist between directly reported LMIC data and surrogate high-income country (HIC) disease burden estimates of correctible congenital anomalies. Nine online databases were searched for studies reporting incidence and prevalence data on surgically correctible congenital anomalies in LMICs between 2006 and 2017. Two independent reviewers screened titles and abstracts, with a third adjudicating discrepancies. Selected studies were reviewed and analyzed. Of 10,128 identified articles, 98 were extracted for full-text review, and 41 were included, representing 21 LMICs and 18 conditions. Study types included community surveys (34%), prospective (22%) and retrospective (17%) multi-site data, registries (12%), single-site data (12%), and systematic reviews (5%). Data collection periods were 1 to 10 years. The pooled epidemiologic data varied systematically from existing HIC literature, with the incidence of disease being generally lower in LMICs. Marked discrepancies exist between reported epidemiologic...Continue Reading

Citations

Dec 1, 2018·World Journal of Surgery·Dan Poenaru, Justina Onyioza Seyi-Olajide
Dec 23, 2020·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Prabhat Kumar ChaudhariRamandeep Kaur Sokhi
Oct 21, 2019·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Marit L Bovbjerg
May 18, 2021·Intractable & Rare Diseases Research·Lama Mohammed El-AttarYasser Mohammed Moshrif
Jun 11, 2021·World Journal of Surgery·Paul TrucheUNKNOWN Global Initiative for Children’s Surgery
Aug 17, 2021·Frontiers in Medicine·Harnoor DhillonShandar Ahmad

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