Incidence and prevalence of sporadic and hereditary MTC in Denmark 1960-2014: a nationwide study

Endocrine Connections
Jes Sloth MathiesenDanish Thyroid Cancer Group (DATHYRCA)

Abstract

Recent studies have shown a significant increase in the temporal trend of medullary thyroid carcinoma (MTC) incidence. However, it remains unknown to which extent sporadic medullary thyroid carcinoma (SMTC) and hereditary MTC (HMTC) affect the MTC incidence over time. We conducted a nationwide retrospective study using previously described RET and MTC cohorts combined with review of medical records, pedigree comparison and relevant nationwide registries. The study included 474 MTC patients diagnosed in Denmark between 1960 and 2014. In the nationwide period from 1997 to 2014, we recorded a mean age-standardized incidence of all MTC, SMTC and HMTC of 0.19, 0.13 and 0.06 per 100,000 per year, respectively. The average annual percentage change in incidence for all MTC, SMTC and HMTC were 1.0 (P = 0.542), 2.8 (P = 0.125) and -3.1 (P = 0.324), respectively. The corresponding figures for point prevalence at January 1, 2015 were 3.8, 2.5 and 1.3 per 100,000, respectively. The average annual percentage change in prevalence from 1998 to 2015 for all MTC, SMTC and HMTC was 2.8 (P < 0.001), 3.8 (P < 0.001) and 1.5 (P = 0.010), respectively. We found no significant change in the incidence of all MTC, SMTC and HMTC possibly due to our small...Continue Reading

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Citations

Feb 29, 2020·The British Journal of Surgery·A MachensH Dralle
Jan 25, 2019·Visceral Medicine·Theresia Weber
Dec 15, 2018·Endocrine Connections·Jes Sloth MathiesenChristian Godballe
Jan 16, 2019·Journal of Surgical Oncology·Sanne Høxbroe MichaelsenJes Sloth Mathiesen
Jan 9, 2019·Thyroid : Official Journal of the American Thyroid Association·Jes Sloth MathiesenChristian Godballe
Nov 20, 2020·Endocrinology and Metabolism·Hwa Young AhnSin Gon Kim
Feb 20, 2021·Nature Reviews. Endocrinology·Domenico SalvatoreMartin Schlumberger
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Apr 1, 2021·The Journal of Clinical Endocrinology and Metabolism·Andreas MachensHenning Dralle
Jun 23, 2021·The British Journal of Surgery·D-J van BeekUNKNOWN EUROCRINE® Council
Sep 21, 2021·Journal of Pediatric Endocrinology & Metabolism : JPEM·Felix EckeltJuergen Kratzsch

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