Incidence and prognosis of central nervous system infections in a birth cohort of 12,000 children

Scandinavian Journal of Infectious Diseases
P RantakallioL von Wendt

Abstract

All types of central nervous system (CNS) infections were investigated in a 1966 birth cohort of 12,000 children from Northern Finland followed up from birth to the age of 14. 174 CNS infections occurred in 167 children, 110 boys and 64 girls. The annual incidence of bacterial CNS infections was 36.3/100,000 and that of viral infections 688.0/100 000. It is concluded that bacterial CNS infections were recorded very fully but only 2/3 of the viral infections could be traced, even though the more severe cases were quite well documented. 8/55 children (14.5%) with bacterial meningitis died; the corresponding figure for viral encephalitis and meningitis (excluding mumps) was 3/67 (4.5%). 17/55 (30.9%) developed mental retardation, epilepsy, cerebral palsy or hearing defect or some combination of these after bacterial CNS infection, and 9 (8.1%) after viral infection. The difference with respect to the children who had not experienced CNS infection was statistically significant only for the bacterial infection cases. CNS infections explained 7.6% of all deaths from 28 days to 14 years, 3% of the handicapping cases of cerebral palsy, mental retardation and epilepsy or some combination of these, and 6.6% of the hearing defects.

References

Jul 1, 1985·European Journal of Pediatrics·L von WendtH Mäkinen
Jan 1, 1970·Scandinavian Journal of Infectious Diseases·P RantakallioR Mäntyjärvi
Jul 28, 1983·The American Journal of Medicine·R Gold

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Citations

Jun 27, 2008·Current Treatment Options in Neurology·Larry E Davis
Feb 23, 2002·Diagnostic Microbiology and Infectious Disease·Thomas Watkins-RiedelPeter Hufnagl
Jul 2, 2002·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·K A StellrechtR A Venezia
May 6, 2010·The Journal of Laryngology and Otology·S I IbrahimD A Nunez
Dec 13, 1990·The New England Journal of Medicine·S L PomeroyR D Feigin
Jun 4, 2005·The Pediatric Infectious Disease Journal·Samir S ShahSusan E Coffin
Oct 2, 2003·Pediatric Case Reviews·Jason G NewlandTheoklis E Zaoutis
Sep 9, 2008·Epilepsia·Jagaralapudi Murali K Murthy, Sudesh Prabhakar
Jan 5, 2008·BMJ : British Medical Journal·Sarah A E Logan, Eithne MacMahon
Sep 11, 2012·BMC Pediatrics·Christine KellyUNKNOWN Northwest Neurological Infections Network
Jul 4, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael A GalicQuentin J Pittman
May 31, 2014·Neurobiology of Disease·Piero PeruccaCarol Camfield
Aug 26, 1998·European Journal of Radiology·G Bennett, J M Provenzale
Dec 3, 2015·Pediatrics in Review·Douglas Swanson
Jun 24, 2014·Journal of Paediatrics and Child Health·Philip N BrittonCheryl A Jones
Mar 31, 2015·Frontiers in Cellular Neuroscience·Christian SchwerkHorst Schroten
May 9, 2016·European Journal of Pediatrics·S C M de CromC C Obihara
Jun 18, 2016·Mediators of Inflammation·Tobias DahmTobias Tenenbaum
Feb 1, 1988·The Journal of Hospital Infection·E G Dowsett
Jan 25, 2017·Current Opinion in Infectious Diseases·Fiona McGillTom Solomon
Nov 4, 2000·Pediatrics International : Official Journal of the Japan Pediatric Society·R Tatara, H Imai
Jan 1, 1988·Paediatric and Perinatal Epidemiology·P Rantakallio
Apr 1, 2016·The Pediatric Infectious Disease Journal·Sarah E Forgie
Aug 2, 2016·Jundishapur Journal of Microbiology·Mohammad Javad Ghabouli ShahroodiMohammad Saeed Sasan
Jul 31, 2001·Dental Traumatology : Official Publication of International Association for Dental Traumatology·U PerheentupaK Oikarinen
May 1, 1991·Developmental Medicine and Child Neurology·M Dalton, R W Newton
Oct 27, 2017·American Journal of Physiology. Cell Physiology·Alexa N LauerChristian Schwerk
Jul 5, 2017·Frontiers in Immunology·Melanie A RuffnerSarah E Henrickson
Nov 1, 1989·The Journal of Infection·C DayJ Walker

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