Incidence and Prognosis of Subsequent Cholangiocarcinoma in Patients with Hepatic Resection for Bile Duct Stones

Digestive Diseases and Sciences
Hyun Jung KimSeon Mee Park

Abstract

Cholangiocarcinoma (CCA) often develops after the hepatic resection for hepatolithiasis as well as indwelling it. We studied the incidence and prognosis of subsequent CCA in patients with hepatolithiasis in South Korea. We identified individuals with diagnosed CCA at the time of or after surgery, during 2002-2016, from the Korean National Health Insurance. The incidences and survival rates of subsequent CCA were analyzed and compared with concomitant CCA. The standardized incidence ratios (SIRs) of CCA in this cohort were evaluated in the standard Korean population. All data were stratified by the presence of intrahepatic or extrahepatic CCA, age and sex. Of the 7852 patients with hepatectomy for BDS, 433 (5.84%) had concomitant CCA. Over the 12-year follow-up, 107 of 7419 (1.98%) patients were diagnosed with subsequent CCA. Patients with hepatic resection for BDS revealed higher SIRs for subsequent CCA (12.89, 95% CI 10.96-15.15) in cases of both intrahepatic CCA (13.40, 10.55-17.02) and extrahepatic CCA (12.42, 9.98-15.46). The median survival time for subsequent CCA was 0.87 years, while that for concomitant CCA was 2.79 years. Having subsequent CCA (HR 2.71, 95% CI 2.17-3.40) and being male (HR 1.28, 1.05-1.57) were related...Continue Reading

References

May 1, 1992·Journal of Gastroenterology and Hepatology·S T Fan, J Wong
Mar 11, 2000·Digestive Diseases and Sciences·M F ChenT S Yeh
Aug 9, 2002·Journal of Gastroenterology and Hepatology·Cheng-Chi LeeGran-Hum Chen
Dec 21, 2005·Journal of Hepato-biliary-pancreatic Surgery·Tamotsu KurokiTakashi Kanematsu
Jul 11, 2006·World Journal of Gastroenterology : WJG·Shao-Qiang LiDong-Ming Li
Jul 13, 2006·Annals of the Royal College of Surgeons of England·Marco CatenaGianfranco Ferla
Mar 6, 2007·World Journal of Surgery·Tung-Yen LeeShou-Jen Kuo
Aug 11, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Tania M WelzelKatherine A McGlynn
Mar 3, 2009·American Journal of Surgery·Takahiro UenishiShoji Kubo
Apr 14, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Gia L Tyson, Hashem B El-Serag
Dec 8, 2011·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Zhen-Yu LiuZheng-Feng Yin
Dec 14, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yutaka SuzukiYutaka Atomi
Aug 28, 2012·Journal of the American College of Surgeons·Parissa TabrizianSasan Roayaie
Feb 2, 2013·World Journal of Gastroenterology : WJG·Chia-Cheng LinYao-Li Chen
Aug 10, 2013·Journal of Gastroenterology and Hepatology·Rohyun SungSeon Mee Park
Nov 23, 2013·Journal of Korean Medical Science·Jin-Seok ParkShin Goo Park
Jan 7, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A GuglielmiC Iacono
May 16, 2014·Journal of Hepato-biliary-pancreatic Sciences·Yutaka SuzukiMasanori Sugiyama
Jul 30, 2014·Journal of Hepato-biliary-pancreatic Sciences·Toshio TsuyuguchiOsamu Yokosuka
May 13, 2015·Best Practice & Research. Clinical Gastroenterology·Annika Bergquist, Erik von Seth
Jan 6, 2016·World Journal of Gastroenterology : WJG·Hyo Jung KimYoung-Tae Bak
May 18, 2016·The Korean Journal of Parasitology·Young-Il JeongShin-Hyeong Cho
Oct 22, 2016·World Journal of Surgery·Ze-Wu MengYan-Ling Chen
Mar 7, 2017·Annals of Hepato-biliary-pancreatic Surgery·Hyeong Min ParkEun Kyu Park

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