Incidence and prognostic significance of t(14;18) translocation in follicle center cell lymphoma of low and high grade. A report from southern Sweden

Annals of Oncology : Official Journal of the European Society for Medical Oncology
A JohnsonH Anderson

Abstract

The t(14;18)(q21;q32) is the most common recurrent genetic defect in follicle center cell lymphoma (FCC). Conflicting reports exist in regard to a possible prognostic significance for the translocation. In a single center, 102 patients with either low-grade (n = 50) or high-grade (n = 52) FCC (Kiel classification) and a median follow-up of 82 months were retrospectively studied to determine survival in relation to t(14;18) as shown by either PCR of the bcl-2 rearrangement in paraffinized tissue or karyotype analysis. t(14;18) was detected in 30 of 50 (60%) low-grade FCC and in 12 of 52 (23%) high-grade FCC. The presence of the t(14;18) was not related to morphologic bone marrow involvement or other clinical parameters, but it was related to age: in low-grade FCC, patients with t(14;18) were an average of 17 years younger (p = 0.002) than those without the translocation. In the group with high-grade histology, 30% survived beyond 60 months regardless of t(14;18) status (p = 0.92). Patients with low-grade histology and t(14;18) fared better than those without, irrespective of age (p = 0.01). No significant difference in disease-free survival related to t(14;18) was found in either low- or high-grade FCC. The incidence of t(14;18)...Continue Reading

Citations

Dec 4, 1998·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·I HosteinP Soubeyran
Mar 24, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Michael DictorEva Rambech
May 31, 2001·British Journal of Haematology·G PapakonstantinouR Hehlmann

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