Incidence and relevance of secondary chromosome abnormalities in childhood TEL/AML1+ acute lymphoblastic leukemia: an interphase FISH analysis

Leukemia
A AttarbaschiAustrian Berlin-Frankfurt-Münster cooperative study group

Abstract

The aim of the present study was to determine the frequency and clinical relevance of the most common secondary karyotype abnormalities in TEL/AML1+ B-cell precursor acute lymphoblastic leukemia (ALL) as assessed with fluorescence in situ hybridization (FISH) analyses. Screening of 372 patients who were enrolled in two consecutive Austrian childhood ALL multicenter trials identified 94 (25%) TEL/AML1+ cases. TEL deletions, trisomy 21 and an additional der(21)t(12;21) were detected in 52 (55%), 13 (14%) and 14 (15%) TEL/AML1+ patients, respectively. The 12p aberrations (P=0.001) and near tetraploidy (P=0.045) were more common in TEL/AML1+ patients, whereas the incidence of diploidy, pseudodiploidy, hypodiploidy, low hyperdiploidy, near triploidy, del(6q), chromosome 9 and 11q23 abnormalities was similar among TEL/AML1+ and TEL/AML1- patients. None of the TEL/AML1+ patients had a high hyperdiploid karyotype. Univariate analysis indicated that among TEL/AML1+ patients those with a deletion of the nontranslocated TEL allele had a worse prognosis than those without this abnormality (P=0.034). We concluded that the type and incidence of the most common secondary aberrations in TEL/AML1+ ALL can be conveniently identified with little ...Continue Reading

References

Mar 1, 1994·Genes, Chromosomes & Cancer·S P RomanaR Berger
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·T R GolubD G Gilliland
Aug 8, 1996·Biochimica Et Biophysica Acta·T R GolubD G Gilliland
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·A M FordM Greaves
Mar 20, 1999·Current Opinion in Pediatrics·A BorkhardtF Lampert
May 1, 2001·British Journal of Haematology·I HubeekA J Veerman
Jun 4, 2002·Current Opinion in Hematology·Mignon L Loh, Jeffrey E Rubnitz
Jul 10, 2003·Cancer Genetics and Cytogenetics·Nathalie Douet-GuilbertMarc De Braekeleer

❮ Previous
Next ❯

Citations

Apr 25, 2012·Pathology Oncology Research : POR·Irén HaltrichGyörgy Fekete
Aug 12, 2010·The Journal of Biological Chemistry·Tadi Satish KumarSathees C Raghavan
Aug 17, 2006·Journal of Pediatric Hematology/oncology·Erik ForestierUNKNOWN Nordic Society of Paediatric Haematology and Oncology NOPHO
Nov 26, 2009·Journal of Pediatric Hematology/oncology·Manuel SteinerUNKNOWN Austrian Berlin-Frankfurt-Münster Study Group
Dec 14, 2005·Journal of Pediatric Hematology/oncology·Stefanos I PapadhimitriouF Athanassiadou
Jul 16, 2005·Pediatric Hematology and Oncology·Manuel SteinerUNKNOWN Austrian Berlin-Frankfurt-Münster Group
Nov 6, 2013·Leukemia & Lymphoma·Katerina KatsibardiFotini Tzortzatou-Stathopoulou
Oct 15, 2009·Hematology/oncology Clinics of North America·Krzysztof MrózekPeter D Aplan
May 6, 2009·Genes, Chromosomes & Cancer·Kajsa Paulsson, Bertil Johansson
Mar 23, 2006·Genes, Chromosomes & Cancer·Andishe AttarbaschiUNKNOWN Austrian Berlin-Frankfurt-Münster Cooperative Study Group
Feb 5, 2008·British Journal of Haematology·Erik ForestierUNKNOWN NOPHO Leukaemia Cytogenetic Study Group (NLCSG)
Sep 13, 2006·British Journal of Haematology·Kristina KarrmanUNKNOWN Nordic Society of Paediatric Haematology and Oncology (NOPHO) and the NOPHO Leukaemia Cytogenetic Study Group (NLCSG)
Jun 10, 2006·Pediatric Blood & Cancer·Suleimman A Al-SweedanBetsy A Hirsch
Feb 8, 2007·Genes, Chromosomes & Cancer·Erik ForestierUNKNOWN NOPHO Leukemia Cytogenetic Study Group (NLCSG)
Oct 19, 2012·Genes, Chromosomes & Cancer·Halima Al-ShehhiAnthony V Moorman
Aug 13, 2010·British Journal of Haematology·Christine J HarrisonUNKNOWN Biology and Diagnosis Committee of International Berlin-Frankfürt-Münster study group
Dec 10, 2009·Genes, Chromosomes & Cancer·Zoë J KonnChristine J Harrison
Jun 19, 2015·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Ansar HakeemA R Lone
Apr 12, 2016·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Cigdem AydinSibel Berker Karauzum
Oct 18, 2012·Case Reports in Genetics·Marina Araújo Fonzar HernandesMaria Luiza Macedo Silva
Aug 11, 2016·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Jae Wook LeeHack-Ki Kim
May 12, 2017·The Biochemical Journal·Elitza Deltcheva, Rachael Nimmo
Mar 18, 2005·Pediatric Hematology and Oncology·Manuel SteinerGeorg Mann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.