Incidence and risk factors for esophageal cancer following achalasia treatment: national population-based case-control study

Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus
Sheraz MarkarG B Hanna

Abstract

The objective of this study is to identify the incidence of and risk factors associated with the development of esophageal cancer in treated achalasia patients in a national cohort. Patients with esophageal achalasia diagnosed and receiving a treatment between 2002 and 2012 were identified in England. Patient and treatment factors were compared between individuals who developed esophageal cancer and those that did not using univariate and multivariate analyses. A total of 7487 patients receiving an interventional treatment for esophageal achalasia were included and 101 patients (1.3%) developed esophageal cancer. The incidence of esophageal cancer was 205 cases per 100,000 patient years at risk. Patients who developed esophageal cancer were older and more commonly primarily treated with pneumatic dilation (82.2% vs. 60.3%; P < 0.001). In the esophageal cancer group, there was an increase in the number of patients requiring reinterventions (47.5% vs. 38.0%; P = 0.041) and the average total number of reinterventions per patient (1.2 vs. 0.8; P = 0.026). Multivariate analysis suggested associations between increased reintervention following both surgical myotomy (HR = 5.1; 95%CI 1.12-23.16) and pneumatic dilation (HR = 1.48; 95%CI...Continue Reading

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Citations

Aug 9, 2019·Journal of Global Oncology·Mariane C L MartinsJosé B C Carvalheira
Aug 11, 2020·The American Journal of Gastroenterology·Michael F VaeziRobert T Kavitt
Feb 5, 2021·Journal of Gastroenterology·Hiroki SatoHaruhiro Inoue

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