Abstract
The incidence, risk factors, and clinical features of hepatocellular carcinoma (HCC) in primary biliary cirrhosis (PBC) have been a long-standing subject of interest. We took advantage of a large cohort of 1865 well-defined Chinese patients with PBC for whom follow-up was conducted for up to 20 years to study the incidence of HCC. Our goal was to address the incidence and prevalence of HCC in PBC and the risk factors, including hepatitis B virus (HBV) infection, and finally to compare the tumor characteristics of PBC-related HCC, including size, location, mortality, and long-term outcomes, to that of HBV-related HCC. In this cohort, HCC occurred in 70 of 1865 PBC patients with a prevalence of 3.75 % and an incidence of 0.66 cases per 100 patient-years. The 5- and 10-year cumulative incidences were 2.6 % (95 % confidence interval (CI) 1.8-3.4) and 8.9 % (95 % CI 5.5-12.3), respectively. Age >54 years (odds ratio [OR] = 5.5, 95 % CI 3.0-10.1, p = 0.001), male sex (OR = 2.2, 95 % CI 1.2-4.0, p = 0.001), co-existence of diabetes mellitus (DM) (OR = 3.1, 95 % CI 1.6-6.2, p = 0.002), and previous HBV infection (OR = 6.6, 95 % CI 3.7-11.9, p = 0.001) were independently associated with the development of HCC. The tumor size, number, lo...Continue Reading
References
Jun 15, 1985·Lancet·S N ZamanR Williams
Sep 1, 1994·Journal of Hepatology·F FarinatiM Chiaramonte
Jul 14, 1999·Gut·H MarusawaT Chiba
Jun 8, 2001·Journal of Hepatology·F TrevisaniM Bernardi
Jun 30, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C BréchotP Paterlini-Bréchot
May 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Akitaka ShibuyaToshio Morizane
Jul 10, 2003·Autoimmunity Reviews·Jorge FindorM Eric Gershwin
Sep 28, 2004·Surgery Today·Kazuki OhbaHiroaki Kinoshita
Oct 28, 2004·Gastroenterology·Giovanna FattovichFrancesco Donato
Oct 28, 2004·Gastroenterology·Christian Bréchot
Oct 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixUNKNOWN Practice Guidelines Committee, American Association for the Study of Liver Diseases
Nov 23, 2006·Journal of Hepatology·Giovanni RaimondoGiovanni Squadrito
May 2, 2007·Annals of Internal Medicine·Kazuki IkedaTsutomu Chiba
Apr 19, 2008·Journal of Digestive Diseases·Min De ZengUNKNOWN Chinese National Consensus Workshop on Nonalcoholic Fatty Liver Disease
Jun 28, 2008·Scandinavian Journal of Gastroenterology·Shigeru AdachiKatsunori Saigenji
Feb 20, 2009·Journal of Viral Hepatitis·K IkedaH Kumada
Jun 26, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Keith D LindorUNKNOWN American Association for Study of Liver Diseases
Jul 9, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna CavazzaAlbert Parés
Oct 27, 2009·Gastroenterology·Anna S LokUNKNOWN HALT-C Trial Group
Oct 29, 2009·The American Journal of Gastroenterology·Alessandro GranitoPaolo Muratori
Dec 31, 2009·PloS One·Jian LuShengli Bi
Feb 23, 2010·Seminars in Liver Disease·Alejandro FornerJordi Bruix
Nov 26, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Carole MacaronNizar N Zein
Dec 28, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Dimitrios P Bogdanos, Lars Komorowski
Jan 8, 2011·Internal Medicine·Hiromi IshibashiMinoru Nakamura
May 3, 2011·Lancet·Carlo SelmiRoss L Coppel
May 29, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Jing GaoYong-Bing Xiang
Dec 1, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kenichi HaradaYasuni Nakanuma
Jan 1, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chen-Yen YangM Eric Gershwin
Feb 22, 2014·Journal of Autoimmunity·Wenting HuangWilliam M Ridgway
Mar 22, 2014·Journal of Autoimmunity·Yuan YaoZhe-Xiong Lian
May 21, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ana LleoM Eric Gershwin
Jul 22, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lifeng WangFu-Sheng Wang
Jul 22, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jun ZhangM Eric Gershwin
Aug 2, 2014·Seminars in Immunopathology·Evaggelia LiaskouM Eric Gershwin
Jan 9, 2015·Gut·Palak J TrivediUNKNOWN On behalf of the Global PBC Study Group
Citations
Sep 29, 2015·Clinical Reviews in Allergy & Immunology·Fan YangXiong Ma
Mar 22, 2016·Cellular & Molecular Immunology·Zongwen ShuaiM Eric Gershwin
Aug 13, 2015·Clinical Reviews in Allergy & Immunology·Yu-Qing XieZhe-Xiong Lian
Feb 21, 2018·European Journal of Gastroenterology & Hepatology·Yingyu ZhangJunqi Niu
Aug 10, 2017·Rheumatology and Therapy·Carlo Selmi, M Eric Gershwin
Jul 30, 2016·Medicine·Nicola CoppolaItalo F Angelillo
Aug 10, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Cynthia Levy
Oct 27, 2018·Journal of Gastroenterology and Hepatology·Sha ChenJidong Jia
Jan 13, 2016·World Journal of Gastroenterology : WJG·Jinjun WangPatrick S C Leung
Sep 26, 2019·Hepatology International·Na ZengJidong Jia
Jun 25, 2020·Aging·Guangyi JiangXiujun Cai
Dec 15, 2018·Journal of Cellular Physiology·Chengzhi WangMingmei Liao
Feb 23, 2019·Cancer Medicine·Kazuo TaraoKatsuaki Tanaka
Aug 4, 2020·Digestive Diseases and Sciences·Yamini NatarajanFasiha Kanwal
Dec 14, 2016·World Journal of Hepatology·Ying-Qiu Huang
Feb 7, 2018·Hepatology Communications·Tomomi KogisoShinji Uemoto
Apr 4, 2017·Journal of Gastroenterology·Annarosa FloreaniMerrill Eric Gershwin
Dec 4, 2020·Clinical and Molecular Hepatology·Atsushi Tanaka
Nov 25, 2020·Molecular Therapy. Nucleic Acids·Bisha DingWeiyang Lou
Feb 22, 2021·Clinical Rheumatology·Sainan BianFengchun Zhang
Apr 4, 2021·Cancers·Eirini I Rigopoulou, George N Dalekos
May 9, 2021·Cancer Letters·Zhenjun ZhaoQiang Xia
Aug 21, 2021·Virchows Archiv : an International Journal of Pathology·Dustin E BoschMatthew M Yeh