Incidence and risk factors of chronic thromboembolic pulmonary hypertension in patients with diagnosis of pulmonary embolism for the first time in real world

The Clinical Respiratory Journal
Yongping YuShengqing Li

Abstract

The incidence and risk factors of chronic thromboembolic pulmonary hypertension (CTEPH) in patients with acute pulmonary embolism (PE) have been well reported. However, in real world, patients diagnosed with PE for the first time were usually composed of acute PE, sub-acute PE, and chronic PE, and the cumulative incidence and risk factors of CTEPH in this cohort were still unknown. A prospective, long-term, follow-up study was conducted to assess the incidence of symptomatic CTEPH in consecutive patients with PE diagnosed for the first time. Patients with unexplained persistent dyspnea during follow-up underwent transthoracic echocardiography and, if the findings indicated pulmonary hypertension, ventilation-perfusion lung scanning and right heart catheterization. CTEPH was confirmed if perfusion defects were present, mean pulmonary artery pressure (mPAP) ≥25 mmHg and pulmonary artery wedge pressure (PAWP) ≤15 mmHg. The cumulative incidence of CTEPH in patients with PE diagnosed for the first time was 11.2% at 3 months, 12.7% at 1 year, 13.4% at 2 years, and 14.5% at 3 years. The following factors increased the risk of CTEPH: time from symptoms to treatment of PE ≥1 month (odds ratio (OR), 14.77), intermediate (OR, 37.63) to hi...Continue Reading

References

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Citations

Jul 24, 2020·Current Opinion in Pulmonary Medicine·Gerald J MaarmanBrian Allwood
Jan 3, 2021·Journal of Thrombosis and Thrombolysis·Sevinc Sarinc UlasliSule Apras Bilgen
Feb 4, 2021·Journal of the American College of Emergency Physicians Open·Angela F JarmanBrandon C Maughan
Apr 8, 2021·The Journal of International Medical Research·Yunqiang NieMiao Guo
Apr 14, 2021·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Hao-Yun LiuChong-Jen Yu
Aug 20, 2021·Singapore Medical Journal·Cheryl Zhiya ChongKian Keong Poh

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