Incidence and risk factors of post-phototherapy neonatal rebound hyperbilirubinemia

World Journal of Pediatrics : WJP
Ismail Mohamed ElhawaryShahinaz Gamal Eldin Ibrahim

Abstract

To determine the incidence and risk factors of post-phototherapy rebound hyperbilirubinemia because data about bilirubin rebound in neonates are lacking and few studies have concerned this condition. A prospective observational study was conducted on 500 neonates with indirect hyperbilirubinemia who were treated according to standard guidelines. Total serum bilirubin (TSB) was measured at 24-36 h after phototherapy; significant bilirubin rebound (SBR) is considered as increasing TSB that needs reinstitution of phototherapy. A total of 124 (24.9%) neonates developed SBR with TSB increased by 3.4 (2.4-11.2) mg/dL after stopping phototherapy. Multiple logistic regression model revealed the following significant risk factors for rebound: low birth weight (B = 1.3, P <  0.001, OR 3.5), suspected sepsis (B = 2.5, P <  0.001, OR 12.6), exposure to intensive phototherapy (B =  0.83, P =  0.03, OR 2.3), hemolysis (B =  1.2, P <  0.001, OR 3.1), high discharge bilirubin level (B =  0.3, P =  0.001, OR 1.3), and short duration of conventional phototherapy (B =  - 1.2, P <  0.001, OR 0.3). SBR should be considered in neonates with hemolysis, low birth weight, suspected sepsis, short duration of conventional phototherapy, exposure to intens...Continue Reading

References

Mar 3, 1973·British Medical Journal·E L RomanoP L Mollison
Nov 20, 1998·The Journal of Pediatrics·R J YetmanJ Garcia
Oct 13, 1999·The Journal of Pediatrics·M T Del VecchioE R Sundel
Jul 2, 2002·Archives of Pediatrics & Adolescent Medicine·M Jeffrey Maisels, Elizabeth Kring
Jul 3, 2004·Pediatrics·UNKNOWN American Academy of Pediatrics Subcommittee on Hyperbilirubinemia
Jul 3, 2004·Pediatrics·Stanley IpUNKNOWN American Academy of Pediatrics Subcommittee on Hyperbilirubinemia
Oct 30, 2004·Journal of Tropical Pediatrics·Jairo A RodríguezAdriana Saiz
Oct 15, 2005·Archives of Disease in Childhood·M KaplanA I Eidelman
Mar 6, 2007·Archives of Disease in Childhood. Fetal and Neonatal Edition·Neil A Murray, Irene A G Roberts
Dec 19, 2009·Indian Pediatrics·Anuradha BansalDeepak Chawla
Jun 7, 2011·Seminars in Perinatology·Thor Willy Ruud Hansen
Jun 9, 2012·Journal of Perinatology : Official Journal of the California Perinatal Association·M J MaiselsD K Stevenson

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Citations

Mar 7, 2020·Journal of the Chinese Medical Association : JCMA·Yu-Cheng LoYu-Sheng Lee
Nov 25, 2020·American Journal of Perinatology·Hanaa AlmohammadiIslam Nour

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