Incidence and risk factors of probable and proven invasive fungal infection in adult patients receiving allogeneic hematopoietic stem cell transplantation

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
Yao-Chung LiuCheng-Hwai Tzeng

Abstract

To investigate the incidence and risk factors for the occurrence of proven or probable invasive fungal infection (IFI) in adult patients receiving allogeneic hematopoietic stem cell transplantation (HSCT). We retrospectively analyzed 421 patients undergoing HSCT between 2002 and 2013 in our hospital. The risk factors for the occurrence of IFI were analyzed using Cox regression models. Thirty-one patients with the median age of 42 years (range, 19-60 years) developed IFI after HSCT. The post-HSCT IFI incidence was 7.4% and median time from HSCT to the diagnosis of IFI was 139 days (range, 2-1809 days). Of the pretransplant factors, European Group for Blood and Marrow Transplantation (EBMT) risk score > 2 (p = 0.001) and prior history of IFI (p = 0.006) or type 2 diabetes mellitus (DM; p = 0.042) were the significant predictors for post-HSCT IFI in univariate analyses. In multivariate analysis, EBMT risk score > 2 (p = 0.015) and prior history of IFI (p = 0.006) retained significance. Of the post-transplant factors, acute graft-versus-disease (GVHD) overall Grade III-IV (p < 0.001), extensive chronic GVHD (p = 0.002), development of post-transplant lymphoproliferative disorders (p = 0.005), and the use of high-dose steroids (p < ...Continue Reading

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Citations

Feb 18, 2016·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·He WangYing-Chun Xu
Jul 22, 2015·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Ming-Chi LiWen-Chien Ko
Jul 25, 2015·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Xin-Yi Yang, Wei-Ting Chen
Sep 22, 2018·The Laryngoscope·Vivek Pandrangi, Evan R Reiter
Jan 19, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Mizuki WatanabeAkifumi Takaori-Kondo
Mar 13, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Kun-Yin QiuDun-Hua Zhou
Apr 22, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Sergio M GomezLillian Sung
Aug 28, 2020·Blood·Pedro Puerta-AlcaldeDimitrios P Kontoyiannis

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