Incidence and survival of childhood bone cancer in northern England and the West Midlands, 1981-2002.

British Journal of Cancer
R EyreR J Q McNally

Abstract

There is a paucity of population-based studies examining incidence and survival trends in childhood bone tumours. We used high quality data from four population-based registries in England. Incidence patterns and trends were described using Poisson regression. Survival trends were analysed using Cox regression. There were 374 cases of childhood (ages 0-14 years) bone tumours (206 osteosarcomas, 144 Ewing sarcomas, 16 chondrosarcomas, 8 other bone tumours) registered in the period 1981-2002. Overall incidence (per million person years) rates were 2.63 (95% confidence interval (CI) 2.27-2.99) for osteosarcoma, 1.90 (1.58-2.21) for Ewing sarcoma and 0.21 (0.11-0.31) for chondrosarcoma. Incidence of Ewing sarcoma declined at an average rate of 3.1% (95% CI 0.6-5.6) per annum (P=0.04), which may be due to tumour reclassification, but there was no change in osteosarcoma incidence. Survival showed marked improvement over the 20 years (1981-2000) for Ewing sarcoma (hazard ratio (HR) per annum=0.95 95% CI 0.91-0.99; P=0.02). However, no improvement was seen for osteosarcoma patients (HR per annum=1.02 95% CI 0.98-1.05; P=0.35) over this time period. Reasons for failure to improve survival including potential delays in diagnosis, accrual...Continue Reading

References

May 1, 1992·Clinical Oncology : a Journal of the Royal College of Radiologists·K R MuirA H Cameron
Jan 1, 1995·Cancer·R W MillerB Novakovic
Aug 1, 1996·Cancer·J G GurneyL L Robison
Apr 20, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C A StillerUNKNOWN EUROCARE Working Group
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stefan S BielackKurt Winkler
Dec 20, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G GattaUNKNOWN EUROCARE Working Group
Feb 16, 2005·Cancer·Eva Steliarova-FoucherPeter Kaatsch
Aug 22, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C A StillerE Steliarova-Foucher
Aug 22, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C A StillerE Steliarova-Foucher

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Citations

Nov 24, 2012·Acta Oncologica·Joni A SerloMaija Tarkkanen
Sep 10, 2014·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·Rajpal Singh PuniaHarsh Mohan
May 20, 2011·Clinical Pediatrics·Aman ChauhanRaj Warrier
Mar 5, 2009·Apoptosis : an International Journal on Programmed Cell Death·John Inge JohnsenMarie Arsenian Henriksson
Jul 21, 2009·Pediatric Blood & Cancer·Rachel EyreRichard J Q McNally
Jan 6, 2016·British Journal of Cancer·Hanna MogensenMaria Feychting
Sep 22, 2011·British Journal of Cancer·N O BastaR J Q McNally
Sep 9, 2015·American Journal of Medical Genetics. Part a·Audrey HochartPierre Leblond
Sep 14, 2011·International Journal of Cancer. Journal International Du Cancer·Jeremy WhelanSandra J Strauss
Apr 16, 2014·Pediatrics International : Official Journal of the Japan Pediatric Society·Tatsuya MorishimaKen-ichiro Watanabe
May 8, 2021·International Journal of Cancer. Journal International Du Cancer·Logan G SpectorJoshua D Schiffman
May 9, 2021·International Journal of Cancer. Journal International Du Cancer·Gabriela A RojasLogan G Spector
Jul 30, 2021·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Francesco MuratoriDomenico Andrea Campanacci

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