Incidence and temporal pattern of anorexia, diarrhea, weight loss, and leukopenia in patients with cervical cancer treated with concurrent radiation therapy and weekly cisplatin: comparison with radiation therapy alone

Gynecologic Oncology
Tatsuya OhnoHirohiko Tsujii

Abstract

To investigate the temporal patterns of anorexia, diarrhea, weight loss, and leukopenia in chemoradiation therapy (CRT) for cervical cancer compared with radiation therapy (RT) alone. Acute toxicities in 43 patients receiving RT alone and 40 patients receiving CRT were retrospectively analyzed. Patients were treated with a combination of external beam irradiation and high-dose rate intracavitary irradiation. Cisplatin was given once a week for 5 weeks concurrently with the external beam irradiation. CRT was divided into low-dose CRT group (cisplatin, 20-30 mg/m(2), n = 16) and high-dose CRT group (cisplatin, 35-40 mg/m(2), n = 24). Toxicities were evaluated before, every week up to 7 weeks during the cycle, and 12 weeks after initial irradiation, according to the National Cancer Institute Common Toxicity Criteria version 2. In the high-dose CRT group, anorexia during the first 5 weeks, leukopenia after 5 weeks, and weight loss after 3 weeks were significantly higher than those in the RT alone group. In the low-dose CRT group, anorexia between 1 and 2 weeks, leukopenia after 5 weeks, and weight loss between 3 and 4 weeks were significantly higher than those in the RT alone group. Diarrhea between 1 and 2 weeks in the high-dose C...Continue Reading

References

Jun 1, 1977·British Journal of Haematology·J M Mishler, P M Emerson
Oct 1, 1992·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·C M LindleyJ T Osterhaus
Apr 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W A PetersD S Alberts
Apr 9, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Brigette MaPhilip J Johnson
Aug 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patricia J EifelHoward Thames
Feb 25, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M J MillwardJ F Bishop
Sep 18, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·John M KirwanChristopher J Williams
Dec 31, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Adriano PaccagnellaUNKNOWN GSTVP (Gruppo di Studio Tumori Polmonari del Veneto)
Dec 14, 2004·Gynecologic Oncology·Akira MitsuhashiSouei Sekiya

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Citations

Sep 2, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Florian StrasserAminah Jatoi
Jan 24, 2014·Journal of Cachexia, Sarcopenia and Muscle·Céline M H Op den KampAnne-Marie C Dingemans
Jun 13, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Yayoi SaegusaHiroshi Takeda
Dec 17, 2016·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Xingxing ChenChanglin Zou
Feb 10, 2018·Journal of the American College of Nutrition·Quadri Kunle AlabiKehinde Peace Olamilosoye
Sep 25, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Yi LiuJiande D Z Chen
Sep 6, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Tomoko KazumotoYoshihiro Saito
Oct 13, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Mika KobayashiHirohiko Tsujii
Aug 23, 2017·Advanced Biomedical Research·Masoomeh NasiriMehdi Nematbakhsh
Nov 19, 2020·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Yong-Qiang LiuYong-Xian Cheng

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