Incidence and therapeutic outcome of pouchitis for ulcerative colitis in Japanese patients

Digestive Surgery
Hiroki IkeuchiTakehira Yamamura

Abstract

The aim of this study was to examine the cumulative risk of pouchitis following restorative proctocolectomy for UC and FAP in Japanese patients, and to assess the response to medical treatment and its outcome. 521 patients with UC and 117 FAP patients underwent proctocolectomy and received a J-shaped IPAA at our department of surgery. We investigated these patients using PDAI for the diagnostic criteria of pouchitis. Pouchitis occurred in only 32 UC patients (6.1%). The cumulative risk of developing pouchitis for a UC patient was 7% at 5 years after and 12% at 10 years after surgery. The medical treatment of acute pouchitis was usually oral metronidazole (250 mg twice daily) for 2 weeks or oral ciprofloxacin (200 mg thrice daily) in patients who could not tolerate metronidazole. Single episodes of pouchitis occurred in 21 patients (65.6%) and chronic or frequent relapses of pouchitis in 11 patients (34.4%). Three patients (9.4%) required re-ileostomy. Two patients (6.3%) required pouch excision. There were no patients with complicated dysplasia. The cumulative risk of pouchitis in Japanese UC patients is lower than that of western countries.

Citations

Dec 21, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Yoshiki OkitaMasato Kusunoki
May 24, 2006·Digestive Surgery·Mitsuhiro NakamuraTakehira Yamamura
Jun 27, 2014·World Journal of Gastroenterology : WJG·Seung-Bum RyooKyu Joo Park
Mar 17, 2017·Inflammatory Bowel Diseases·Amy L LightnerJohn H Pemberton
Jun 6, 2009·The American Journal of Gastroenterology·Joel H RubensteinPeter D R Higgins
Dec 18, 2008·The American Journal of Gastroenterology·Kelvin T ThiaSuk-Kyun Yang
Jan 17, 2007·The British Journal of Surgery·D HahnloserR R Dozois
Apr 4, 2012·Diseases of the Colon and Rectum·Hideyuki SuzukiIwao Sasaki
Nov 21, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Danujan SriranganathanJonathan P Segal

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